A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1

BACKGROUND: Glucagon-like peptide-1 (GLP-1) (7–36) is a peptide incretin hormone released from the endocrine L-cells of the intestinal mucosa with unique antidiabetic potential. Due to low absorption efficiency and instability in the gastrointestinal tract, the introduction of orally active GLP-1 is...

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Detalles Bibliográficos
Autores principales: Qu, Wei, Li, Yong, Hovgaard, Lars, Li, Song, Dai, Wenbin, Wang, Jiancheng, Zhang, Xuan, Zhang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446861/
https://www.ncbi.nlm.nih.gov/pubmed/23028226
http://dx.doi.org/10.2147/IJN.S30013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446861/
https://www.ncbi.nlm.nih.gov/pubmed/23028226
http://dx.doi.org/10.2147/IJN.S30013

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