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Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

The invasion of Squamous Cell Carcinoma (SCC) is a significant cause of morbidity and mortality. Here we identify an E3 ligase, Traf6, and a de-ubiquitinating enzyme, Cezanne/ZA20D1, as important regulators of this process in organotypic models. Traf6 can promote the formation of Cdc42-dependent F-a...

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Detalles Bibliográficos
Autores principales:	Chaudhry, Shahid I., Hooper, Steven, Nye, Emma, Williamson, Peter, Harrington, Kevin, Sahai, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446864/ https://www.ncbi.nlm.nih.gov/pubmed/22450746 http://dx.doi.org/10.1038/onc.2012.91

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