Cargando…

Direct Engagement of TLR4 in Invariant NKT Cells Regulates Immune Diseases by Differential IL-4 and IFN-γ Production in Mice

During interaction with APCs, invariant (i) NKT cells are thought to be indirectly activated by TLR4-dependently activated APCs. However, whether TLR4 directly activates iNKT cells is unknown. Therefore, the expression and function of TLR4 in iNKT cells were investigated. Flow cytometric and confoca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Ji Hyung, Kim, Hye Sung, Kim, Hye Young, Oh, Sae Jin, Chung, Doo Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446883/ https://www.ncbi.nlm.nih.gov/pubmed/23028952 http://dx.doi.org/10.1371/journal.pone.0045348

Ejemplares similares

TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation
por: Kim, Hye Sung, et al.
Publicado: (2012)

Combination of NKT14m and Low Dose IL-12 Promotes Invariant Natural Killer T Cell IFN-γ Production and Tumor Control
por: Guan, Peng, et al.
Publicado: (2020)

Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA)
por: Oh, Sae Jin, et al.
Publicado: (2011)

Intracellular IL-4 and IFN-γ expression in iNKT cells from patients with chronic lymphocytic leukemia
por: Bojarska-Junak, Agnieszka, et al.
Publicado: (2018)

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
por: Koh, Jaemoon, et al.
Publicado: (2023)

In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells
por: Wang, Xiaowen, et al.
Publicado: (2001)

Accumulation of invariant NKT cells with increased IFN-γ production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia
por: Hu, Ting, et al.
Publicado: (2015)

TIM-4 is expressed on invariant NKT cells but dispensable for their development and function
por: Zhang, Xilin, et al.
Publicado: (2016)

Invariant NKT cells: Killers and conspirators against cancer
por: Bassiri, Hamid, et al.
Publicado: (2013)

The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8(+ )NKT-like cells
por: Zhou, Li, et al.
Publicado: (2008)

SOX4 controls invariant NKT cell differentiation by tuning TCR signaling
por: Malhotra, Nidhi, et al.
Publicado: (2018)

TLR4 and NKT Cell Synergy in Immunotherapy against Visceral Leishmaniasis
por: Karmakar, Subir, et al.
Publicado: (2012)

Thymic stromal lymphopoietin production in DN32.D3 invariant natural killer T (iNKT) cell line and primary mouse liver iNKT cells
por: Choi, Jun-Pyo, et al.
Publicado: (2021)

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
por: Spiller, Stephan, et al.
Publicado: (2008)

TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
por: Spiller, Stephan, et al.
Publicado: (2008)

Antigen-Specific IFN-γ/IL-17-Co-Producing CD4(+) T-Cells are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine
por: Choi, Han-Gyu, et al.
Publicado: (2020)

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
por: Colombo, Giorgia, et al.
Publicado: (2022)

Expressions of IL4, IL10, and IFNγ cytokines genes during bacterial mastitis
por: Faaz, Rana A., et al.
Publicado: (2022)

IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils
por: Kummola, Laura, et al.
Publicado: (2023)

Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis
por: Kim, Geun-Tae, et al.
Publicado: (2009)

NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor β1 production
por: Kim, Hye Young, et al.
Publicado: (2005)

Intracellular Bacterial Infection and Invariant NKT Cells
por: Emoto, Masashi, et al.
Publicado: (2009)

The Impact of Invariant NKT Cells in Sterile Inflammation: The Possible Contribution of the Alarmin/Cytokine IL-33
por: Ferhat, Maroua Haroun, et al.
Publicado: (2018)

STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction
por: Sikorski, Krzysztof, et al.
Publicado: (2012)

Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38(−/−) Mice
por: Li, Qi, et al.
Publicado: (2019)

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation
por: Won, Hee Yeun, et al.
Publicado: (2021)

Predictive Value of Serum IFN-γ inducible Protein-10 and IFN-γ/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients
por: Wang, Yadong, et al.
Publicado: (2017)

Human IL-21(+)IFN-γ(+)CD4(+) T cells in nasal polyps are regulated by IL-12
por: Xiao, Li, et al.
Publicado: (2015)

Mycobacterium tuberculosis-Specific IL-21(+)IFN-γ(+)CD4(+) T Cells Are Regulated by IL-12
por: Li, Li, et al.
Publicado: (2016)

CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia
por: Raballah, Evans, et al.
Publicado: (2017)

IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13
por: Moynihan, Barry J, et al.
Publicado: (2008)

Plasma Levels of IFN-γ, IL-4, IL-6 and IL-17 in HIV-Positive Patients With Oral Candidiasis
por: Ayatollahi Mousavi, Seyyed Amin, et al.
Publicado: (2016)

Cigarette Smoking Triggers Colitis by IFN-γ(+) CD4(+) T Cells
por: Lee, Gihyun, et al.
Publicado: (2017)

Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation
por: Hwang, Eun-Ha, et al.
Publicado: (2016)

The TLR4–TRIF–type 1 IFN–IFN-γ pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
por: Yamamoto, Koji, et al.
Publicado: (2021)

Improved Detection of Cytokines Produced by Invariant NKT Cells
por: Sag, Duygu, et al.
Publicado: (2017)

Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells
por: Qin, Yingyu, et al.
Publicado: (2019)

Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
por: He, Tingyan, et al.
Publicado: (2023)

IL-4, IL-10, TNF-α and IFN-γ Cytokine Levels in Patients with Cystic Echinococcosis and Fascioliasis
por: Beyhan, Yunus Emre, et al.
Publicado: (2022)

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
por: Kang, Kyuho, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b7bofnrg0046er1jo8fergvtte