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Treatment with Activated Protein C (aPC) Is Protective during the Development of Myocardial Fibrosis: An Angiotensin II Infusion Model in Mice

AIMS: Myocardial fibrosis contributes to the development of heart failure. Activated Protein C (aPC) is a circulating anticoagulant with anti-inflammatory and cytoprotective properties. Using a model of myocardial fibrosis second to Angiotensin II (AngII) infusion, we investigated the novel therapeu...

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Detalles Bibliográficos
Autores principales:	Sopel, Mryanda J., Rosin, Nicole L., Falkenham, Alec G., Bezuhly, Michael, Esmon, Charles T., Lee, Timothy D. G., Liwski, Robert S., Légaré, Jean-Francois
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446915/ https://www.ncbi.nlm.nih.gov/pubmed/23029168 http://dx.doi.org/10.1371/journal.pone.0045663

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