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Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults
Although low executive functioning is a risk factor for vehicle crashes among elderly drivers, the neural basis of individual differences in this cognitive ability remains largely unknown. Here we aimed to examine regional frontal gray matter volume associated with executive functioning in normal ag...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446941/ https://www.ncbi.nlm.nih.gov/pubmed/23029316 http://dx.doi.org/10.1371/journal.pone.0045920 |
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author | Sakai, Hiroyuki Takahara, Miwa Honjo, Naomi F. Doi, Shun'ichi Sadato, Norihiro Uchiyama, Yuji |
author_facet | Sakai, Hiroyuki Takahara, Miwa Honjo, Naomi F. Doi, Shun'ichi Sadato, Norihiro Uchiyama, Yuji |
author_sort | Sakai, Hiroyuki |
collection | PubMed |
description | Although low executive functioning is a risk factor for vehicle crashes among elderly drivers, the neural basis of individual differences in this cognitive ability remains largely unknown. Here we aimed to examine regional frontal gray matter volume associated with executive functioning in normal aging individuals, using voxel-based morphometry (VBM). To this end, 39 community-dwelling elderly volunteers who drove a car on a daily basis participated in structural magnetic resonance imaging, and completed two questionnaires concerning executive functioning and risky driving tendencies in daily living. Consequently, we found that participants with low executive function capacity were prone to risky driving. Furthermore, VBM analysis revealed that lower executive function capacity was associated with smaller gray matter volume in the supplementary motor area (SMA). Thus, the current data suggest that SMA volume is a reliable predictor of individual differences in executive function capacity as a risk factor for vehicle crashes among elderly persons. The implication of our results is that regional frontal gray matter volume might underlie the variation in driving tendencies among elderly drivers. Therefore, detailed driving behavior assessments might be able to detect early neurodegenerative changes in the frontal lobe in normal aging adults. |
format | Online Article Text |
id | pubmed-3446941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34469412012-10-01 Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults Sakai, Hiroyuki Takahara, Miwa Honjo, Naomi F. Doi, Shun'ichi Sadato, Norihiro Uchiyama, Yuji PLoS One Research Article Although low executive functioning is a risk factor for vehicle crashes among elderly drivers, the neural basis of individual differences in this cognitive ability remains largely unknown. Here we aimed to examine regional frontal gray matter volume associated with executive functioning in normal aging individuals, using voxel-based morphometry (VBM). To this end, 39 community-dwelling elderly volunteers who drove a car on a daily basis participated in structural magnetic resonance imaging, and completed two questionnaires concerning executive functioning and risky driving tendencies in daily living. Consequently, we found that participants with low executive function capacity were prone to risky driving. Furthermore, VBM analysis revealed that lower executive function capacity was associated with smaller gray matter volume in the supplementary motor area (SMA). Thus, the current data suggest that SMA volume is a reliable predictor of individual differences in executive function capacity as a risk factor for vehicle crashes among elderly persons. The implication of our results is that regional frontal gray matter volume might underlie the variation in driving tendencies among elderly drivers. Therefore, detailed driving behavior assessments might be able to detect early neurodegenerative changes in the frontal lobe in normal aging adults. Public Library of Science 2012-09-19 /pmc/articles/PMC3446941/ /pubmed/23029316 http://dx.doi.org/10.1371/journal.pone.0045920 Text en © 2012 Sakai et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sakai, Hiroyuki Takahara, Miwa Honjo, Naomi F. Doi, Shun'ichi Sadato, Norihiro Uchiyama, Yuji Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title | Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title_full | Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title_fullStr | Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title_full_unstemmed | Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title_short | Regional Frontal Gray Matter Volume Associated with Executive Function Capacity as a Risk Factor for Vehicle Crashes in Normal Aging Adults |
title_sort | regional frontal gray matter volume associated with executive function capacity as a risk factor for vehicle crashes in normal aging adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446941/ https://www.ncbi.nlm.nih.gov/pubmed/23029316 http://dx.doi.org/10.1371/journal.pone.0045920 |
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