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Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice

Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiologi...

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Autores principales: Mukai, Rie, Horikawa, Hitomi, Fujikura, Yutaka, Kawamura, Tomoyuki, Nemoto, Hisao, Nikawa, Takeshi, Terao, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446978/
https://www.ncbi.nlm.nih.gov/pubmed/23028754
http://dx.doi.org/10.1371/journal.pone.0045048
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author Mukai, Rie
Horikawa, Hitomi
Fujikura, Yutaka
Kawamura, Tomoyuki
Nemoto, Hisao
Nikawa, Takeshi
Terao, Junji
author_facet Mukai, Rie
Horikawa, Hitomi
Fujikura, Yutaka
Kawamura, Tomoyuki
Nemoto, Hisao
Nikawa, Takeshi
Terao, Junji
author_sort Mukai, Rie
collection PubMed
description Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.
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spelling pubmed-34469782012-10-01 Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice Mukai, Rie Horikawa, Hitomi Fujikura, Yutaka Kawamura, Tomoyuki Nemoto, Hisao Nikawa, Takeshi Terao, Junji PLoS One Research Article Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake. Public Library of Science 2012-09-19 /pmc/articles/PMC3446978/ /pubmed/23028754 http://dx.doi.org/10.1371/journal.pone.0045048 Text en © 2012 Mukai et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mukai, Rie
Horikawa, Hitomi
Fujikura, Yutaka
Kawamura, Tomoyuki
Nemoto, Hisao
Nikawa, Takeshi
Terao, Junji
Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title_full Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title_fullStr Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title_full_unstemmed Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title_short Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
title_sort prevention of disuse muscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446978/
https://www.ncbi.nlm.nih.gov/pubmed/23028754
http://dx.doi.org/10.1371/journal.pone.0045048
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