The Anti-Cancer IgM Monoclonal Antibody PAT-SM6 Binds with High Avidity to the Unfolded Protein Response Regulator GRP78

The monoclonal IgM antibody PAT-SM6 derived from human tumours induces apoptosis in tumour cells and is considered a potential anti-cancer agent. A primary target for PAT-SM6 is the unfolded protein response regulator GRP78, over-expressed externally on the cell surface of tumour cells. Small angle...

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Detalles Bibliográficos
Autores principales: Rosenes, Zachary, Mulhern, Terrence D., Hatters, Danny M., Ilag, Leodevico L., Power, Barbara E., Hosking, Chris, Hensel, Frank, Howlett, Geoffrey J., Mok, Yee-Foong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446985/
https://www.ncbi.nlm.nih.gov/pubmed/23028685
http://dx.doi.org/10.1371/journal.pone.0044927

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