Nitric oxide rescues thalidomide mediated teratogenicity

Thalidomide, a sedative drug given to pregnant women, unfortunately caused limb deformities in thousands of babies. Recently the drug was revived because of its therapeutic potential; however the search is still ongoing for an antidote against thalidomide induced limb deformities. In the current stu...

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Detalles Bibliográficos
Autores principales: Siamwala, Jamila H., Veeriah, Vimal, Priya, M. Krishna, Rajendran, Saranya, Saran, Uttara, Sinha, Swaraj, Nagarajan, Shunmugam, T, Pradeep, Chatterjee, Suvro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447183/
https://www.ncbi.nlm.nih.gov/pubmed/22997553
http://dx.doi.org/10.1038/srep00679
Descripción
Sumario:Thalidomide, a sedative drug given to pregnant women, unfortunately caused limb deformities in thousands of babies. Recently the drug was revived because of its therapeutic potential; however the search is still ongoing for an antidote against thalidomide induced limb deformities. In the current study we found that nitric oxide (NO) rescues thalidomide affected chick (Gallus gallus) and zebrafish (Danio rerio) embryos. This study confirms that NO reduced the number of thalidomide mediated limb deformities by 94% and 80% in chick and zebrafish embryos respectively. NO prevents limb deformities by promoting angiogenesis, reducing oxidative stress and inactivating caspase-3 dependent apoptosis. We conclude that NO secures angiogenesis in the thalidomide treated embryos to protect them from deformities.

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