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The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we e...

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Detalles Bibliográficos
Autores principales: Comi, Cristoforo, Cappellano, Giuseppe, Chiocchetti, Annalisa, Orilieri, Elisabetta, Buttini, Sara, Ghezzi, Laura, Galimberti, Daniela, Guerini, Franca, Barizzone, Nadia, Perla, Franco, Leone, Maurizio, D'Alfonso, Sandra, Caputo, Domenico, Scarpini, Elio, Cantello, Roberto, Dianzani, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447190/
https://www.ncbi.nlm.nih.gov/pubmed/23008732
http://dx.doi.org/10.1155/2012/212893
Descripción
Sumario:Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5′ end on the −156G > GG single nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on the +1239A > C SNP. We found that only +1239A > C SNP displayed a statistically significant association with MS development, but both +1239A > C and −156G > GG had an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only. Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses.