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The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we e...

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Autores principales: Comi, Cristoforo, Cappellano, Giuseppe, Chiocchetti, Annalisa, Orilieri, Elisabetta, Buttini, Sara, Ghezzi, Laura, Galimberti, Daniela, Guerini, Franca, Barizzone, Nadia, Perla, Franco, Leone, Maurizio, D'Alfonso, Sandra, Caputo, Domenico, Scarpini, Elio, Cantello, Roberto, Dianzani, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447190/
https://www.ncbi.nlm.nih.gov/pubmed/23008732
http://dx.doi.org/10.1155/2012/212893
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author Comi, Cristoforo
Cappellano, Giuseppe
Chiocchetti, Annalisa
Orilieri, Elisabetta
Buttini, Sara
Ghezzi, Laura
Galimberti, Daniela
Guerini, Franca
Barizzone, Nadia
Perla, Franco
Leone, Maurizio
D'Alfonso, Sandra
Caputo, Domenico
Scarpini, Elio
Cantello, Roberto
Dianzani, Umberto
author_facet Comi, Cristoforo
Cappellano, Giuseppe
Chiocchetti, Annalisa
Orilieri, Elisabetta
Buttini, Sara
Ghezzi, Laura
Galimberti, Daniela
Guerini, Franca
Barizzone, Nadia
Perla, Franco
Leone, Maurizio
D'Alfonso, Sandra
Caputo, Domenico
Scarpini, Elio
Cantello, Roberto
Dianzani, Umberto
author_sort Comi, Cristoforo
collection PubMed
description Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5′ end on the −156G > GG single nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on the +1239A > C SNP. We found that only +1239A > C SNP displayed a statistically significant association with MS development, but both +1239A > C and −156G > GG had an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only. Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses.
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spelling pubmed-34471902012-09-24 The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression Comi, Cristoforo Cappellano, Giuseppe Chiocchetti, Annalisa Orilieri, Elisabetta Buttini, Sara Ghezzi, Laura Galimberti, Daniela Guerini, Franca Barizzone, Nadia Perla, Franco Leone, Maurizio D'Alfonso, Sandra Caputo, Domenico Scarpini, Elio Cantello, Roberto Dianzani, Umberto Clin Dev Immunol Research Article Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5′ end on the −156G > GG single nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on the +1239A > C SNP. We found that only +1239A > C SNP displayed a statistically significant association with MS development, but both +1239A > C and −156G > GG had an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only. Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses. Hindawi Publishing Corporation 2012 2012-09-11 /pmc/articles/PMC3447190/ /pubmed/23008732 http://dx.doi.org/10.1155/2012/212893 Text en Copyright © 2012 Cristoforo Comi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Comi, Cristoforo
Cappellano, Giuseppe
Chiocchetti, Annalisa
Orilieri, Elisabetta
Buttini, Sara
Ghezzi, Laura
Galimberti, Daniela
Guerini, Franca
Barizzone, Nadia
Perla, Franco
Leone, Maurizio
D'Alfonso, Sandra
Caputo, Domenico
Scarpini, Elio
Cantello, Roberto
Dianzani, Umberto
The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title_full The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title_fullStr The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title_full_unstemmed The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title_short The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
title_sort impact of osteopontin gene variations on multiple sclerosis development and progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447190/
https://www.ncbi.nlm.nih.gov/pubmed/23008732
http://dx.doi.org/10.1155/2012/212893
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