The Role of Circadian Clocks in Metabolic Disease

The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with per...

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Detalles Bibliográficos
Autores principales: Li, Min-Dian, Li, Chao-Min, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447202/
https://www.ncbi.nlm.nih.gov/pubmed/23012586
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author Li, Min-Dian
Li, Chao-Min
Wang, Zhong
author_facet Li, Min-Dian
Li, Chao-Min
Wang, Zhong
author_sort Li, Min-Dian
collection PubMed
description The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues.
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spelling pubmed-34472022012-09-25 The Role of Circadian Clocks in Metabolic Disease Li, Min-Dian Li, Chao-Min Wang, Zhong Yale J Biol Med Review The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues. YJBM 2012-09-25 /pmc/articles/PMC3447202/ /pubmed/23012586 Text en Copyright ©2012, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Review
Li, Min-Dian
Li, Chao-Min
Wang, Zhong
The Role of Circadian Clocks in Metabolic Disease
title The Role of Circadian Clocks in Metabolic Disease
title_full The Role of Circadian Clocks in Metabolic Disease
title_fullStr The Role of Circadian Clocks in Metabolic Disease
title_full_unstemmed The Role of Circadian Clocks in Metabolic Disease
title_short The Role of Circadian Clocks in Metabolic Disease
title_sort role of circadian clocks in metabolic disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447202/
https://www.ncbi.nlm.nih.gov/pubmed/23012586
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