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Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus

The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian i...

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Autores principales: Chua, Tze-Hoong, Leung, Connie Y. H., Fang, H. E., Chow, Chun-Kin, Ma, Siu-Kit, Sia, Sin-Fun, Ng, Iris H. Y., Fenwick, Stanley G., James, Cassandra M., Chua, Sin Bin, Chew, Siang Thai, Kwang, Jimmy, Peiris, J. S. M., Ellis, Trevor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447282/
https://www.ncbi.nlm.nih.gov/pubmed/23074648
http://dx.doi.org/10.1155/2010/489213
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author Chua, Tze-Hoong
Leung, Connie Y. H.
Fang, H. E.
Chow, Chun-Kin
Ma, Siu-Kit
Sia, Sin-Fun
Ng, Iris H. Y.
Fenwick, Stanley G.
James, Cassandra M.
Chua, Sin Bin
Chew, Siang Thai
Kwang, Jimmy
Peiris, J. S. M.
Ellis, Trevor M.
author_facet Chua, Tze-Hoong
Leung, Connie Y. H.
Fang, H. E.
Chow, Chun-Kin
Ma, Siu-Kit
Sia, Sin-Fun
Ng, Iris H. Y.
Fenwick, Stanley G.
James, Cassandra M.
Chua, Sin Bin
Chew, Siang Thai
Kwang, Jimmy
Peiris, J. S. M.
Ellis, Trevor M.
author_sort Chua, Tze-Hoong
collection PubMed
description The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.
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spelling pubmed-34472822012-10-16 Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus Chua, Tze-Hoong Leung, Connie Y. H. Fang, H. E. Chow, Chun-Kin Ma, Siu-Kit Sia, Sin-Fun Ng, Iris H. Y. Fenwick, Stanley G. James, Cassandra M. Chua, Sin Bin Chew, Siang Thai Kwang, Jimmy Peiris, J. S. M. Ellis, Trevor M. Influenza Res Treat Research Article The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems. Hindawi Publishing Corporation 2010 2010-06-27 /pmc/articles/PMC3447282/ /pubmed/23074648 http://dx.doi.org/10.1155/2010/489213 Text en Copyright © 2010 Tze-Hoong Chua et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chua, Tze-Hoong
Leung, Connie Y. H.
Fang, H. E.
Chow, Chun-Kin
Ma, Siu-Kit
Sia, Sin-Fun
Ng, Iris H. Y.
Fenwick, Stanley G.
James, Cassandra M.
Chua, Sin Bin
Chew, Siang Thai
Kwang, Jimmy
Peiris, J. S. M.
Ellis, Trevor M.
Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title_full Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title_fullStr Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title_full_unstemmed Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title_short Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
title_sort evaluation of a subunit h5 vaccine and an inactivated h5n2 avian influenza marker vaccine in ducks challenged with vietnamese h5n1 highly pathogenic avian influenza virus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447282/
https://www.ncbi.nlm.nih.gov/pubmed/23074648
http://dx.doi.org/10.1155/2010/489213
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