Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fu...

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Autores principales: Osaki, Tomohiro, Azuma, Kazuo, Kurozumi, Seiji, Takamori, Yoshimori, Tsuka, Takeshi, Imagawa, Tomohiro, Okamoto, Yoshiharu, Minami, Saburo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447342/
https://www.ncbi.nlm.nih.gov/pubmed/23015778
http://dx.doi.org/10.3390/md10081873
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author Osaki, Tomohiro
Azuma, Kazuo
Kurozumi, Seiji
Takamori, Yoshimori
Tsuka, Takeshi
Imagawa, Tomohiro
Okamoto, Yoshiharu
Minami, Saburo
author_facet Osaki, Tomohiro
Azuma, Kazuo
Kurozumi, Seiji
Takamori, Yoshimori
Tsuka, Takeshi
Imagawa, Tomohiro
Okamoto, Yoshiharu
Minami, Saburo
author_sort Osaki, Tomohiro
collection PubMed
description D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
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spelling pubmed-34473422012-09-26 Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs Osaki, Tomohiro Azuma, Kazuo Kurozumi, Seiji Takamori, Yoshimori Tsuka, Takeshi Imagawa, Tomohiro Okamoto, Yoshiharu Minami, Saburo Mar Drugs Article D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β). MDPI 2012-08-22 /pmc/articles/PMC3447342/ /pubmed/23015778 http://dx.doi.org/10.3390/md10081873 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Osaki, Tomohiro
Azuma, Kazuo
Kurozumi, Seiji
Takamori, Yoshimori
Tsuka, Takeshi
Imagawa, Tomohiro
Okamoto, Yoshiharu
Minami, Saburo
Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_full Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_fullStr Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_full_unstemmed Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_short Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_sort metabolomic analyses of blood plasma after oral administration of d-glucosamine hydrochloride to dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447342/
https://www.ncbi.nlm.nih.gov/pubmed/23015778
http://dx.doi.org/10.3390/md10081873
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