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DNA Methylation and Gene Expression Profiling of Ewing Sarcoma Primary Tumors Reveal Genes That Are Potential Targets of Epigenetic Inactivation

The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded EWS tumors and 3 EWS cell lines was compared to human mesenchymal stem cell primary cultures (hMSCs) using bead chip methylation analysis. Re...

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Detalles Bibliográficos
Autores principales:	Patel, Nikul, Black, Jennifer, Chen, Xi, Marcondes, A. Mario, Grady, William M., Lawlor, Elizabeth R., Borinstein, Scott C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447379/ https://www.ncbi.nlm.nih.gov/pubmed/23024594 http://dx.doi.org/10.1155/2012/498472

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