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Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells

The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcita...

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Detalles Bibliográficos
Autores principales: Aprea, Julieta, Calegari, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447385/
https://www.ncbi.nlm.nih.gov/pubmed/23024660
http://dx.doi.org/10.1155/2012/816049
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author Aprea, Julieta
Calegari, Federico
author_facet Aprea, Julieta
Calegari, Federico
author_sort Aprea, Julieta
collection PubMed
description The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated.
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spelling pubmed-34473852012-09-28 Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells Aprea, Julieta Calegari, Federico Stem Cells Int Review Article The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated. Hindawi Publishing Corporation 2012 2012-09-11 /pmc/articles/PMC3447385/ /pubmed/23024660 http://dx.doi.org/10.1155/2012/816049 Text en Copyright © 2012 J. Aprea and F. Calegari. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Aprea, Julieta
Calegari, Federico
Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title_full Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title_fullStr Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title_full_unstemmed Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title_short Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
title_sort bioelectric state and cell cycle control of mammalian neural stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447385/
https://www.ncbi.nlm.nih.gov/pubmed/23024660
http://dx.doi.org/10.1155/2012/816049
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