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Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells
The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcita...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447385/ https://www.ncbi.nlm.nih.gov/pubmed/23024660 http://dx.doi.org/10.1155/2012/816049 |
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author | Aprea, Julieta Calegari, Federico |
author_facet | Aprea, Julieta Calegari, Federico |
author_sort | Aprea, Julieta |
collection | PubMed |
description | The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated. |
format | Online Article Text |
id | pubmed-3447385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34473852012-09-28 Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells Aprea, Julieta Calegari, Federico Stem Cells Int Review Article The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated. Hindawi Publishing Corporation 2012 2012-09-11 /pmc/articles/PMC3447385/ /pubmed/23024660 http://dx.doi.org/10.1155/2012/816049 Text en Copyright © 2012 J. Aprea and F. Calegari. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aprea, Julieta Calegari, Federico Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title | Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title_full | Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title_fullStr | Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title_full_unstemmed | Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title_short | Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells |
title_sort | bioelectric state and cell cycle control of mammalian neural stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447385/ https://www.ncbi.nlm.nih.gov/pubmed/23024660 http://dx.doi.org/10.1155/2012/816049 |
work_keys_str_mv | AT apreajulieta bioelectricstateandcellcyclecontrolofmammalianneuralstemcells AT calegarifederico bioelectricstateandcellcyclecontrolofmammalianneuralstemcells |