Cargando…
On the use of photoacoustics to detect red blood cell aggregation
The feasibility of detecting red blood cell (RBC) aggregation with photoacoustics (PAs) was investigated theoretically and experimentally using human and porcine RBCs. The theoretical PA signals and spectra generated from such samples were examined for several hematocrit levels and aggregates sizes....
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447572/ https://www.ncbi.nlm.nih.gov/pubmed/23024924 http://dx.doi.org/10.1364/BOE.3.002326 |
_version_ | 1782244115458555904 |
---|---|
author | Hysi, Eno Saha, Ratan K. Kolios, Michael C. |
author_facet | Hysi, Eno Saha, Ratan K. Kolios, Michael C. |
author_sort | Hysi, Eno |
collection | PubMed |
description | The feasibility of detecting red blood cell (RBC) aggregation with photoacoustics (PAs) was investigated theoretically and experimentally using human and porcine RBCs. The theoretical PA signals and spectra generated from such samples were examined for several hematocrit levels and aggregates sizes. The effect of a finite transducer bandwidth on the received PA signal was also examined. The simulation results suggest that the dominant frequency of the PA signals from non-aggregated RBCs decreases towards clinical frequency ranges as the aggregate size increases. The experimentally measured mean spectral power increased by ~6 dB for the largest aggregate compared to the non-aggregated samples. Such results confirm the theoretical predictions and illustrate the potential of using PA imaging for detecting RBC aggregation. |
format | Online Article Text |
id | pubmed-3447572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-34475722012-09-28 On the use of photoacoustics to detect red blood cell aggregation Hysi, Eno Saha, Ratan K. Kolios, Michael C. Biomed Opt Express Photoacoustic Imaging and Spectroscopy The feasibility of detecting red blood cell (RBC) aggregation with photoacoustics (PAs) was investigated theoretically and experimentally using human and porcine RBCs. The theoretical PA signals and spectra generated from such samples were examined for several hematocrit levels and aggregates sizes. The effect of a finite transducer bandwidth on the received PA signal was also examined. The simulation results suggest that the dominant frequency of the PA signals from non-aggregated RBCs decreases towards clinical frequency ranges as the aggregate size increases. The experimentally measured mean spectral power increased by ~6 dB for the largest aggregate compared to the non-aggregated samples. Such results confirm the theoretical predictions and illustrate the potential of using PA imaging for detecting RBC aggregation. Optical Society of America 2012-08-30 /pmc/articles/PMC3447572/ /pubmed/23024924 http://dx.doi.org/10.1364/BOE.3.002326 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Photoacoustic Imaging and Spectroscopy Hysi, Eno Saha, Ratan K. Kolios, Michael C. On the use of photoacoustics to detect red blood cell aggregation |
title | On the use of photoacoustics to detect red blood cell aggregation |
title_full | On the use of photoacoustics to detect red blood cell aggregation |
title_fullStr | On the use of photoacoustics to detect red blood cell aggregation |
title_full_unstemmed | On the use of photoacoustics to detect red blood cell aggregation |
title_short | On the use of photoacoustics to detect red blood cell aggregation |
title_sort | on the use of photoacoustics to detect red blood cell aggregation |
topic | Photoacoustic Imaging and Spectroscopy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447572/ https://www.ncbi.nlm.nih.gov/pubmed/23024924 http://dx.doi.org/10.1364/BOE.3.002326 |
work_keys_str_mv | AT hysieno ontheuseofphotoacousticstodetectredbloodcellaggregation AT saharatank ontheuseofphotoacousticstodetectredbloodcellaggregation AT koliosmichaelc ontheuseofphotoacousticstodetectredbloodcellaggregation |