Cargando…

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives

A new series of pyrazolo[3,4-d]pyrimidines has been synthesized. The new compounds were tested for their antitumor activity on 60 different cell lines, and some of the compounds were found to have potent antitumor activity. In particular, 2-hydroxybenzaldehyde [1-(4-chlorophenyl)-3-methyl-1H-pyrazol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kandeel, Manal M., Mohamed, Lamia W., Abd El Hamid, Mohammed K., Negmeldin, Ahmed T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447607/ https://www.ncbi.nlm.nih.gov/pubmed/23008804 http://dx.doi.org/10.3797/scipharm.1204-23

Ejemplares similares

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives
por: Abdellatif, Khaled R. A., et al.
Publicado: (2014)

Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines
por: Othman, Eman M., et al.
Publicado: (2021)

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
por: Salem, Ibrahim M., et al.
Publicado: (2022)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Crystal structure of 4-allylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

Crystal structure of 1-ethylpyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2014)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
por: Greco, Chiara, et al.
Publicado: (2020)

Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Antitumor Agents: Exploratory Synthesis, Preliminary Structure-Activity Relationships, and in Vitro Biological Evaluation
por: He, Hai-Yun, et al.
Publicado: (2011)

Crystal structure of 1-methyl-4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Design, synthesis, and biological evaluation with molecular dynamics study of novel pyrazolo[3,4-d]pyrimidine derivatives as anti-cancer agents
por: Shaban, Rania M., et al.
Publicado: (2023)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

Computational Approaches for the Design of Novel Anticancer Compounds Based on Pyrazolo[3,4-d]pyrimidine Derivatives as TRAP1 Inhibitor
por: Ali, Amena, et al.
Publicado: (2021)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors
por: Mahnashi, Mater, et al.
Publicado: (2023)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
por: Mandour, Asmaa A., et al.
Publicado: (2022)

Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-ones
por: El-Tombary, Alaa A.
Publicado: (2013)

One-Flask Synthesis of Pyrazolo[3,4-d]pyrimidines from 5-Aminopyrazoles and Mechanistic Study
por: Yen, Wan-Ping, et al.
Publicado: (2017)

The crystal structure of 1,5-dibenzyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2015)

Synthesis of some novel pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives as potential antimicrobial agent
por: Sureja, Dipen K., et al.
Publicado: (2016)

A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
por: Liu, Mingxing, et al.
Publicado: (2015)

Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor
por: Contadini, Claudia, et al.
Publicado: (2023)

Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors
por: AbdElhameid, Mohammed K., et al.
Publicado: (2018)

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR(WT) and EGFR(T790M)
por: Gaber, Ahmed A., et al.
Publicado: (2022)

Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-d]pyrimidin-4-ones
por: Ng, Jia Hui, et al.
Publicado: (2022)

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
por: Vignaroli, Giulia, et al.
Publicado: (2016)

Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold
por: Baillache, Daniel J., et al.
Publicado: (2020)

Synthesis of Some Novel Pyrazolo[1,5-a]pyrimidine Derivatives and Their Application as Disperse Dyes
por: Al-Etaibi, Alya M., et al.
Publicado: (2011)

The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
por: Ambjørner, Sophie E. B., et al.
Publicado: (2020)

Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells
por: Kostić, Ana, et al.
Publicado: (2021)

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
por: Wu, Xiaowei, et al.
Publicado: (2021)

Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
por: Fouda, Ahmed M., et al.
Publicado: (2019)

The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl(4)-Induced Liver Fibrosis in Rats
por: Ghobrial, Diana K., et al.
Publicado: (2023)

Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position
por: Al-Afaleq, Eljazi I., et al.
Publicado: (2001)

The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
por: Rango, Enrico, et al.
Publicado: (2022)

Design, Synthesis, In Vitro, and In Silico Studies of New N(5)-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors
por: Zaki, Waheed A., et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Novel Pleuromutilin Derivatives Containing 6-Chloro-1-R-1H-pyrazolo[3,4-d]pyrimidine-4-amino Side Chain
por: Wang, Jun, et al.
Publicado: (2023)

Design and synthesis of novel pyrazolo[4,3-d]pyrimidines as potential therapeutic agents for acute lung injury
por: Wang, Bao Shi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qvh0e6t8opv0purkg5hjlqpp9c