Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after meta...

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Detalles Bibliográficos
Autores principales: Unger, Pascal, Melzig, Matthias F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447612/
https://www.ncbi.nlm.nih.gov/pubmed/23008813
http://dx.doi.org/10.3797/scipharm.1204-21
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author Unger, Pascal
Melzig, Matthias F.
author_facet Unger, Pascal
Melzig, Matthias F.
author_sort Unger, Pascal
collection PubMed
description The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
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spelling pubmed-34476122012-09-24 Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone Unger, Pascal Melzig, Matthias F. Sci Pharm Short Communication The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-05-31 /pmc/articles/PMC3447612/ /pubmed/23008813 http://dx.doi.org/10.3797/scipharm.1204-21 Text en © Unger and Melzig; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Unger, Pascal
Melzig, Matthias F.
Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title_full Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title_fullStr Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title_full_unstemmed Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title_short Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
title_sort comparative study of the cytotoxicity and genotoxicity of alpha- and beta-asarone
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447612/
https://www.ncbi.nlm.nih.gov/pubmed/23008813
http://dx.doi.org/10.3797/scipharm.1204-21
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