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Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine
A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited exc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Österreichische Apotheker-Verlagsgesellschaft
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447615/ https://www.ncbi.nlm.nih.gov/pubmed/23008821 http://dx.doi.org/10.3797/scipharm.1205-15 |
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author | Choudhary, Dhagla R. Patel, Vishnu A. Chhalotiya, Usmangani K. Patel, Harsha V. Kundawala, Aliasgar J. |
author_facet | Choudhary, Dhagla R. Patel, Vishnu A. Chhalotiya, Usmangani K. Patel, Harsha V. Kundawala, Aliasgar J. |
author_sort | Choudhary, Dhagla R. |
collection | PubMed |
description | A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited excellent stability for four months when stored at 40 °C and 75% humidity. In vitro dissolution studies suggested a rapid disintegration, in which most of levocetirizine (93.54 ± 3.9%) dissolved within 90 seconds after insertion into the medium. Subsequently, Sprague–Dawley rats were used to compare the pharmacokinetic properties of the film preparation administered to the oral cavity, to those with oral administration of the pure drug solution. The pharmacokinetic parameters were similar between the two groups in which AUC(0–t) (ng h/ml), AUC(0–∞) (ng h/ml) C(max) (ng/ml), T(max) (min), K(el) (h(−1)), and t(1/2) (h) of the reference were 452.033 ± 43.68, 465.78 ± 48.16, 237.16 ± 19.87, 30, 0.453 ± 0.051, and 1.536 ± 0.118, respectively, for the film formulation 447.233 ± 46.24, 458.22 ± 46.74, 233.32 ± 17.19, 30, 0.464 ± 0.060, and 1.496 ± 0.293, respectively. These results suggest that the present levocetirizine containing fast-dissolving film is likely to become one of the choices to treat different allergic conditions. |
format | Online Article Text |
id | pubmed-3447615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Österreichische Apotheker-Verlagsgesellschaft |
record_format | MEDLINE/PubMed |
spelling | pubmed-34476152012-09-24 Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine Choudhary, Dhagla R. Patel, Vishnu A. Chhalotiya, Usmangani K. Patel, Harsha V. Kundawala, Aliasgar J. Sci Pharm Research Article A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited excellent stability for four months when stored at 40 °C and 75% humidity. In vitro dissolution studies suggested a rapid disintegration, in which most of levocetirizine (93.54 ± 3.9%) dissolved within 90 seconds after insertion into the medium. Subsequently, Sprague–Dawley rats were used to compare the pharmacokinetic properties of the film preparation administered to the oral cavity, to those with oral administration of the pure drug solution. The pharmacokinetic parameters were similar between the two groups in which AUC(0–t) (ng h/ml), AUC(0–∞) (ng h/ml) C(max) (ng/ml), T(max) (min), K(el) (h(−1)), and t(1/2) (h) of the reference were 452.033 ± 43.68, 465.78 ± 48.16, 237.16 ± 19.87, 30, 0.453 ± 0.051, and 1.536 ± 0.118, respectively, for the film formulation 447.233 ± 46.24, 458.22 ± 46.74, 233.32 ± 17.19, 30, 0.464 ± 0.060, and 1.496 ± 0.293, respectively. These results suggest that the present levocetirizine containing fast-dissolving film is likely to become one of the choices to treat different allergic conditions. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-07-22 /pmc/articles/PMC3447615/ /pubmed/23008821 http://dx.doi.org/10.3797/scipharm.1205-15 Text en © Choudhary et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Choudhary, Dhagla R. Patel, Vishnu A. Chhalotiya, Usmangani K. Patel, Harsha V. Kundawala, Aliasgar J. Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title | Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title_full | Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title_fullStr | Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title_full_unstemmed | Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title_short | Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine |
title_sort | development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447615/ https://www.ncbi.nlm.nih.gov/pubmed/23008821 http://dx.doi.org/10.3797/scipharm.1205-15 |
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