Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation

A new method for the simultaneous determination of celecoxib, erlotinib, and its active metabolite desmethyl-erlotinib (OSI-420) in rat plasma, by liquid chromatography/tandem mass spectrometry with positive/negative ion-switching electrospray ionization mode, was developed and validated. Protein pr...

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Detalles Bibliográficos
Autores principales: Thappali, Satheeshmanikandan R. S., Varanasi, Kanthikiran, Veeraraghavan, Sridhar, Arla, Rambabu, Chennupati, Sandhya, Rajamanickam, Madheswaran, Vakkalanka, Swaroop, Khagga, Mukkanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447620/
https://www.ncbi.nlm.nih.gov/pubmed/23008811
http://dx.doi.org/10.3797/scipharm.1205-09

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