Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents

rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4′,3′:4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized comp...

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Detalles Bibliográficos
Autores principales: Kryshchyshyn, Anna, Atamanyuk, Dmytro, Lesyk, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447621/
https://www.ncbi.nlm.nih.gov/pubmed/23008803
http://dx.doi.org/10.3797/scipharm.1204-02
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author Kryshchyshyn, Anna
Atamanyuk, Dmytro
Lesyk, Roman
author_facet Kryshchyshyn, Anna
Atamanyuk, Dmytro
Lesyk, Roman
author_sort Kryshchyshyn, Anna
collection PubMed
description rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4′,3′:4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized compounds were evaluated for their anticancer activity in NCI60 cell lines. Among the tested compounds, 3f was found to be the most active candidate with the greatest influence on leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, prostate cancer, and breast cancer subpanel cell lines with GI(50) values over a range of 0.37–0.67 μM.
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spelling pubmed-34476212012-09-24 Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents Kryshchyshyn, Anna Atamanyuk, Dmytro Lesyk, Roman Sci Pharm Research Article rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4′,3′:4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized compounds were evaluated for their anticancer activity in NCI60 cell lines. Among the tested compounds, 3f was found to be the most active candidate with the greatest influence on leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, prostate cancer, and breast cancer subpanel cell lines with GI(50) values over a range of 0.37–0.67 μM. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-05-03 /pmc/articles/PMC3447621/ /pubmed/23008803 http://dx.doi.org/10.3797/scipharm.1204-02 Text en © Kryshchyshyn et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kryshchyshyn, Anna
Atamanyuk, Dmytro
Lesyk, Roman
Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title_full Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title_fullStr Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title_full_unstemmed Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title_short Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
title_sort fused thiopyrano[2,3-d]thiazole derivatives as potential anticancer agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447621/
https://www.ncbi.nlm.nih.gov/pubmed/23008803
http://dx.doi.org/10.3797/scipharm.1204-02
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