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Impaired distensibility of ascending aorta in patients with HIV infection
BACKGROUND: Our aim was to investigate the aortic distensibility (AD) of the ascending aorta and carotid artery intima-media thickness (c-IMT) in HIV-infected patients compared to healthy controls. METHODS: One hundred and five HIV-infected patients (86 males [82%], mean age 41 ± 0.92 years), and 12...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447671/ https://www.ncbi.nlm.nih.gov/pubmed/22846182 http://dx.doi.org/10.1186/1471-2334-12-167 |
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author | Zormpala, Alexandra Sipsas, Nikolaos V Moyssakis, Ioannis Georgiadou, Sarah P Gamaletsou, Maria N Kontos, Athanasios N Ziakas, Panayiotis D Kordossis, Theodore |
author_facet | Zormpala, Alexandra Sipsas, Nikolaos V Moyssakis, Ioannis Georgiadou, Sarah P Gamaletsou, Maria N Kontos, Athanasios N Ziakas, Panayiotis D Kordossis, Theodore |
author_sort | Zormpala, Alexandra |
collection | PubMed |
description | BACKGROUND: Our aim was to investigate the aortic distensibility (AD) of the ascending aorta and carotid artery intima-media thickness (c-IMT) in HIV-infected patients compared to healthy controls. METHODS: One hundred and five HIV-infected patients (86 males [82%], mean age 41 ± 0.92 years), and 124 age and sex matched HIV-1 uninfected controls (104 males [84%], mean age 39.2 ± 1.03 years) were evaluated by high-resolution ultrasonography to determine AD and c-IMT. For all patients and controls clinical and laboratory factors associated with atherosclerosis were recorded. RESULTS: HIV- infected patients had reduced AD compared to controls: 2.2 ± 0.01 vs. 2.62 ± 0.01 10(-6) cm(2) dyn(-1), respectively (p < 0.001). No difference was found in c-IMT between the two groups. In multiadjusted analysis, HIV infection was independently associated with decreased distensibility (beta –0.45, p < 0.001). Analysis among HIV-infected patients showed that patients exposed to HAART had decreased AD compared to HAART-naïve patients [mean (SD): 2.18(0.02) vs. 2.28(0.03) 10(-6) cm(2) dyn(-1), p = 0.01]. In multiadjusted analysis, increasing age and exposure to HAART were independently associated with decreased AD. CONCLUSION: HIV infection is independently associated with decreased distensibility of the ascending aorta, a marker of subclinical atherosclerosis. Increasing age and duration of exposure to HAART are factors further contributing to decreased AD. |
format | Online Article Text |
id | pubmed-3447671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34476712012-09-25 Impaired distensibility of ascending aorta in patients with HIV infection Zormpala, Alexandra Sipsas, Nikolaos V Moyssakis, Ioannis Georgiadou, Sarah P Gamaletsou, Maria N Kontos, Athanasios N Ziakas, Panayiotis D Kordossis, Theodore BMC Infect Dis Research Article BACKGROUND: Our aim was to investigate the aortic distensibility (AD) of the ascending aorta and carotid artery intima-media thickness (c-IMT) in HIV-infected patients compared to healthy controls. METHODS: One hundred and five HIV-infected patients (86 males [82%], mean age 41 ± 0.92 years), and 124 age and sex matched HIV-1 uninfected controls (104 males [84%], mean age 39.2 ± 1.03 years) were evaluated by high-resolution ultrasonography to determine AD and c-IMT. For all patients and controls clinical and laboratory factors associated with atherosclerosis were recorded. RESULTS: HIV- infected patients had reduced AD compared to controls: 2.2 ± 0.01 vs. 2.62 ± 0.01 10(-6) cm(2) dyn(-1), respectively (p < 0.001). No difference was found in c-IMT between the two groups. In multiadjusted analysis, HIV infection was independently associated with decreased distensibility (beta –0.45, p < 0.001). Analysis among HIV-infected patients showed that patients exposed to HAART had decreased AD compared to HAART-naïve patients [mean (SD): 2.18(0.02) vs. 2.28(0.03) 10(-6) cm(2) dyn(-1), p = 0.01]. In multiadjusted analysis, increasing age and exposure to HAART were independently associated with decreased AD. CONCLUSION: HIV infection is independently associated with decreased distensibility of the ascending aorta, a marker of subclinical atherosclerosis. Increasing age and duration of exposure to HAART are factors further contributing to decreased AD. BioMed Central 2012-07-30 /pmc/articles/PMC3447671/ /pubmed/22846182 http://dx.doi.org/10.1186/1471-2334-12-167 Text en Copyright ©2012 Zormpala et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zormpala, Alexandra Sipsas, Nikolaos V Moyssakis, Ioannis Georgiadou, Sarah P Gamaletsou, Maria N Kontos, Athanasios N Ziakas, Panayiotis D Kordossis, Theodore Impaired distensibility of ascending aorta in patients with HIV infection |
title | Impaired distensibility of ascending aorta in patients with HIV infection |
title_full | Impaired distensibility of ascending aorta in patients with HIV infection |
title_fullStr | Impaired distensibility of ascending aorta in patients with HIV infection |
title_full_unstemmed | Impaired distensibility of ascending aorta in patients with HIV infection |
title_short | Impaired distensibility of ascending aorta in patients with HIV infection |
title_sort | impaired distensibility of ascending aorta in patients with hiv infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447671/ https://www.ncbi.nlm.nih.gov/pubmed/22846182 http://dx.doi.org/10.1186/1471-2334-12-167 |
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