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H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to a...

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Detalles Bibliográficos
Autores principales:	van der Vries, Erhard, Collins, Patrick J., Vachieri, Sebastien G., Xiong, Xiaoli, Liu, Junfeng, Walker, Philip A., Haire, Lesley F., Hay, Alan J., Schutten, Martin, Osterhaus, Albert D. M. E., Martin, Steve R., Boucher, Charles A. B., Skehel, John J., Gamblin, Steve J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447749/ https://www.ncbi.nlm.nih.gov/pubmed/23028314 http://dx.doi.org/10.1371/journal.ppat.1002914

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