Cargando…

Adipose Stromal Cells Amplify Angiogenic Signaling via the VEGF/mTOR/Akt Pathway in a Murine Hindlimb Ischemia Model: A 3D Multimodality Imaging Study

Although adipose-derived stromal cell (ADSC) transplantation has been demonstrated as a promising therapeutic strategy for peripheral arterial disease (PAD), the mechanism of action behind the observed therapeutic efficacy of ADSCs remains unclear. This study was designed to investigate the long-ter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Weiwei, Sun, Dongdong, Liu, Junting, Liang, Dong, Wang, Yabin, Narsinh, Kazim H., Li, Yong, Qin, Xing, Liang, Jimin, Tian, Jie, Cao, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447795/ https://www.ncbi.nlm.nih.gov/pubmed/23029141 http://dx.doi.org/10.1371/journal.pone.0045621

Ejemplares similares

Delayed Recovery of Skeletal Muscle Mass following Hindlimb Immobilization in mTOR Heterozygous Mice
por: Lang, Susan M., et al.
Publicado: (2012)

Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors
por: Singleton, Patrick A, et al.
Publicado: (2010)

VEGF-mTOR signaling links obesity and endometrial cancer
por: Sahoo, Subhransu S., et al.
Publicado: (2018)

Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes
por: Tekabe, Yared, et al.
Publicado: (2011)

Ischemia induces autophagy of endothelial cells and stimulates angiogenic effects in a hindlimb ischemia mouse model
por: Jeong, In-Hye, et al.
Publicado: (2020)

Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis
por: Chen, Hongxia, et al.
Publicado: (2015)

VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway
por: Chen, Li, et al.
Publicado: (2020)

Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia
por: Lee, Jun Hee, et al.
Publicado: (2020)

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
por: Allen, Elizabeth, et al.
Publicado: (2016)

Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy
por: Faes, Seraina, et al.
Publicado: (2017)

Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using (111)In-bevacizumab
por: Patel, Neel, et al.
Publicado: (2017)

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
por: Ragunathrao, Vijay Avin Balaji, et al.
Publicado: (2019)

Bone Size and Quality Regulation: Concerted Actions of mTOR in Mesenchymal Stromal Cells and Osteoclasts
por: Wu, Hongguang, et al.
Publicado: (2017)

Anti-angiogenic alternatives to VEGF blockade
por: Khan, Kabir A., et al.
Publicado: (2015)

The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth
por: Wang, Shuo, et al.
Publicado: (2016)

Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin
por: Kida, Teruyo, et al.
Publicado: (2021)

VEGF(121)b and VEGF(165)b are weakly angiogenic isoforms of VEGF-A
por: Catena, Raúl, et al.
Publicado: (2010)

VEGF-A enhances the cytotoxic function of CD4(+) cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
por: Chen, Ziyi, et al.
Publicado: (2023)

Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway
por: Zhou, Huiling, et al.
Publicado: (2023)

Multimodality Imaging Evaluation of Functional and Clinical Benefits of Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion Lesion
por: Sun, Dongdong, et al.
Publicado: (2012)

Therapeutic efficacy of apelin on transplanted mesenchymal stem cells in hindlimb ischemic mice via regulation of autophagy
por: Liang, Dong, et al.
Publicado: (2016)

Murine Model of Hindlimb Ischemia
por: Niiyama, Hiroshi, et al.
Publicado: (2009)

Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF‐1α/VEGF pathway in traumatic brain injury
por: Yuan, Xiaoyu, et al.
Publicado: (2020)

Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus
por: Piha-Paul, Sarina A., et al.
Publicado: (2014)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma
por: Martin-Liberal, J., et al.
Publicado: (2014)

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
por: Antonioli, Eliane, et al.
Publicado: (2019)

H(2)O(2)-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs
por: Chen, Youlu, et al.
Publicado: (2022)

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma
por: Jham, Bruno C., et al.
Publicado: (2011)

Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo
por: Sasore, Temitope, et al.
Publicado: (2014)

Mesenchymal Stromal Cells Combined With Elastin-Like Recombinamers Increase Angiogenesis In Vivo After Hindlimb Ischemia
por: Ibáñez-Fonseca, Arturo, et al.
Publicado: (2022)

Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
por: Künnapuu, Jaana, et al.
Publicado: (2021)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

The clinicopathological and prognostic significance of mTOR and p-mTOR expression in patients with non-small cell lung cancer: A meta-analysis
por: Qiu, Weiwei, et al.
Publicado: (2022)

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
por: Sun, Dongdong, et al.
Publicado: (2020)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway
por: Wang, Yue, et al.
Publicado: (2019)

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
por: Karali, Evdoxia, et al.
Publicado: (2014)

Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer
por: Pal, Krishnendu, et al.
Publicado: (2019)

An experimental model of ischemia in rabbit hindlimb.
por: Hong, J. H., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_kpjen1gmh8kmm4aibid3c4bt0n