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15-Lipoxygenase Metabolites of Docosahexaenoic Acid Inhibit Prostate Cancer Cell Proliferation and Survival

A 15-LOX, it is proposed, suppresses the growth of prostate cancer in part by converting arachidonic, eicosatrienoic, and/or eicosapentaenoic acids to n-6 hydroxy metabolites. These metabolites inhibit the proliferation of PC3, LNCaP, and DU145 prostate cancer cells but only at ≥1–10 µM. We show her...

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Detalles Bibliográficos
Autores principales:	O’Flaherty, Joseph T., Hu, Yungping, Wooten, Rhonda E., Horita, David A., Samuel, Michael P., Thomas, Michael J., Sun, Haiguo, Edwards, Iris J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447860/ https://www.ncbi.nlm.nih.gov/pubmed/23029040 http://dx.doi.org/10.1371/journal.pone.0045480

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