Connection between Genetic and Clinical Data in Bipolar Disorder

Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significan...

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Autores principales: Mellerup, Erling, Andreassen, Ole, Bennike, Bente, Dam, Henrik, Durovic, Srdjan, Hansen, Thomas, Melle, Ingrid, Møller, Gert Lykke, Mors, Ole, Koefoed, Pernille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447882/
https://www.ncbi.nlm.nih.gov/pubmed/23028568
http://dx.doi.org/10.1371/journal.pone.0044623
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author Mellerup, Erling
Andreassen, Ole
Bennike, Bente
Dam, Henrik
Durovic, Srdjan
Hansen, Thomas
Melle, Ingrid
Møller, Gert Lykke
Mors, Ole
Koefoed, Pernille
author_facet Mellerup, Erling
Andreassen, Ole
Bennike, Bente
Dam, Henrik
Durovic, Srdjan
Hansen, Thomas
Melle, Ingrid
Møller, Gert Lykke
Mors, Ole
Koefoed, Pernille
author_sort Mellerup, Erling
collection PubMed
description Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
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spelling pubmed-34478822012-10-01 Connection between Genetic and Clinical Data in Bipolar Disorder Mellerup, Erling Andreassen, Ole Bennike, Bente Dam, Henrik Durovic, Srdjan Hansen, Thomas Melle, Ingrid Møller, Gert Lykke Mors, Ole Koefoed, Pernille PLoS One Research Article Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data. Public Library of Science 2012-09-20 /pmc/articles/PMC3447882/ /pubmed/23028568 http://dx.doi.org/10.1371/journal.pone.0044623 Text en © 2012 Mellerup et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mellerup, Erling
Andreassen, Ole
Bennike, Bente
Dam, Henrik
Durovic, Srdjan
Hansen, Thomas
Melle, Ingrid
Møller, Gert Lykke
Mors, Ole
Koefoed, Pernille
Connection between Genetic and Clinical Data in Bipolar Disorder
title Connection between Genetic and Clinical Data in Bipolar Disorder
title_full Connection between Genetic and Clinical Data in Bipolar Disorder
title_fullStr Connection between Genetic and Clinical Data in Bipolar Disorder
title_full_unstemmed Connection between Genetic and Clinical Data in Bipolar Disorder
title_short Connection between Genetic and Clinical Data in Bipolar Disorder
title_sort connection between genetic and clinical data in bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447882/
https://www.ncbi.nlm.nih.gov/pubmed/23028568
http://dx.doi.org/10.1371/journal.pone.0044623
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