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Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9

Toll-like receptor (TLR)-dependent pathways control the activation of various immune cells and the production of cytokines and chemokines that are important in innate immune control of viruses, including mouse cytomegalovirus (MCMV). Here we report that upon MCMV infection wild-type and TLR7(−/−) ma...

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Autores principales: Traub, Stephanie, Demaria, Olivier, Chasson, Lionel, Serra, Fabienne, Desnues, Benoit, Alexopoulou, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447886/
https://www.ncbi.nlm.nih.gov/pubmed/23028824
http://dx.doi.org/10.1371/journal.pone.0045171
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author Traub, Stephanie
Demaria, Olivier
Chasson, Lionel
Serra, Fabienne
Desnues, Benoit
Alexopoulou, Lena
author_facet Traub, Stephanie
Demaria, Olivier
Chasson, Lionel
Serra, Fabienne
Desnues, Benoit
Alexopoulou, Lena
author_sort Traub, Stephanie
collection PubMed
description Toll-like receptor (TLR)-dependent pathways control the activation of various immune cells and the production of cytokines and chemokines that are important in innate immune control of viruses, including mouse cytomegalovirus (MCMV). Here we report that upon MCMV infection wild-type and TLR7(−/−) male mice were more resistant than their female counterparts, while TLR9(−/−) male and female mice showed similar susceptibility. Interestingly, 36 h upon MCMV infection TLR9 mRNA expression was higher in male than in female mouse spleens. MCMV infection led to stronger reduction of marginal zone (MZ) B cells, and higher infiltration of plasmacytoid dendritic cells and neutrophils in wild-type male than female mice, while no such sex differences were observed in TLR9(−/−) mice. In accordance, the serum levels of KC and MIP-2, major neutrophil chemoattractants, were higher in wild-type, but not in TLR9(−/−), male versus female mice. Wild-type MCMV-infected female mice showed more severe liver inflammation, necrosis and steatosis compared to infected male mice. Our data demonstrate sex differences in susceptibility to MCMV infection, accompanied by a lower activation of the innate immune system in female mice, and can be attributed, at least in a certain degree, to the lower expression of TLR9 in female than male mice.
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spelling pubmed-34478862012-10-01 Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9 Traub, Stephanie Demaria, Olivier Chasson, Lionel Serra, Fabienne Desnues, Benoit Alexopoulou, Lena PLoS One Research Article Toll-like receptor (TLR)-dependent pathways control the activation of various immune cells and the production of cytokines and chemokines that are important in innate immune control of viruses, including mouse cytomegalovirus (MCMV). Here we report that upon MCMV infection wild-type and TLR7(−/−) male mice were more resistant than their female counterparts, while TLR9(−/−) male and female mice showed similar susceptibility. Interestingly, 36 h upon MCMV infection TLR9 mRNA expression was higher in male than in female mouse spleens. MCMV infection led to stronger reduction of marginal zone (MZ) B cells, and higher infiltration of plasmacytoid dendritic cells and neutrophils in wild-type male than female mice, while no such sex differences were observed in TLR9(−/−) mice. In accordance, the serum levels of KC and MIP-2, major neutrophil chemoattractants, were higher in wild-type, but not in TLR9(−/−), male versus female mice. Wild-type MCMV-infected female mice showed more severe liver inflammation, necrosis and steatosis compared to infected male mice. Our data demonstrate sex differences in susceptibility to MCMV infection, accompanied by a lower activation of the innate immune system in female mice, and can be attributed, at least in a certain degree, to the lower expression of TLR9 in female than male mice. Public Library of Science 2012-09-20 /pmc/articles/PMC3447886/ /pubmed/23028824 http://dx.doi.org/10.1371/journal.pone.0045171 Text en © 2012 Traub et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Traub, Stephanie
Demaria, Olivier
Chasson, Lionel
Serra, Fabienne
Desnues, Benoit
Alexopoulou, Lena
Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title_full Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title_fullStr Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title_full_unstemmed Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title_short Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
title_sort sex bias in susceptibility to mcmv infection: implication of tlr9
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447886/
https://www.ncbi.nlm.nih.gov/pubmed/23028824
http://dx.doi.org/10.1371/journal.pone.0045171
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