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B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men

Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP adm...

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Autores principales: Vila, Greisa, Grimm, Gabriele, Resl, Michael, Heinisch, Birgit, Einwallner, Elisa, Esterbauer, Harald, Dieplinger, Benjamin, Mueller, Thomas, Luger, Anton, Clodi, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447894/
https://www.ncbi.nlm.nih.gov/pubmed/22698919
http://dx.doi.org/10.2337/db11-1466
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author Vila, Greisa
Grimm, Gabriele
Resl, Michael
Heinisch, Birgit
Einwallner, Elisa
Esterbauer, Harald
Dieplinger, Benjamin
Mueller, Thomas
Luger, Anton
Clodi, Martin
author_facet Vila, Greisa
Grimm, Gabriele
Resl, Michael
Heinisch, Birgit
Einwallner, Elisa
Esterbauer, Harald
Dieplinger, Benjamin
Mueller, Thomas
Luger, Anton
Clodi, Martin
author_sort Vila, Greisa
collection PubMed
description Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP administration on appetite-regulating hormones and subjective ratings of hunger and satiety in 10 healthy volunteers. Participants received in a randomized, placebo-controlled, crossover, single-blinded study (subject) placebo once and 3.0 pmol/kg/min human BNP-32 once administered as a continuous infusion during 4 h. Circulating concentrations of appetite-regulating peptides were measured hourly. Subjective ratings of hunger and satiety were evaluated by visual analog scales. BNP inhibited the fasting-induced increase in total and acylated ghrelin concentrations over time (P = 0.043 and P = 0.038, respectively). In addition, BNP decreased the subjective rating of hunger (P = 0.009) and increased the feeling of satiety (P = 0.012) when compared with placebo. There were no significant changes in circulating peptide YY, glucagon-like peptide 1, oxyntomodulin, pancreatic polypeptide, leptin, and adiponectin concentrations. In summary, our results demonstrate that BNP exerts anorectic effects and reduces ghrelin concentrations in men. These data, taken together with the known cardiovascular properties of ghrelin, support the existence of a heart–gut–brain axis, which could be therapeutically targeted in patients with heart failure and obesity.
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spelling pubmed-34478942013-10-01 B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men Vila, Greisa Grimm, Gabriele Resl, Michael Heinisch, Birgit Einwallner, Elisa Esterbauer, Harald Dieplinger, Benjamin Mueller, Thomas Luger, Anton Clodi, Martin Diabetes Pathophysiology Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP administration on appetite-regulating hormones and subjective ratings of hunger and satiety in 10 healthy volunteers. Participants received in a randomized, placebo-controlled, crossover, single-blinded study (subject) placebo once and 3.0 pmol/kg/min human BNP-32 once administered as a continuous infusion during 4 h. Circulating concentrations of appetite-regulating peptides were measured hourly. Subjective ratings of hunger and satiety were evaluated by visual analog scales. BNP inhibited the fasting-induced increase in total and acylated ghrelin concentrations over time (P = 0.043 and P = 0.038, respectively). In addition, BNP decreased the subjective rating of hunger (P = 0.009) and increased the feeling of satiety (P = 0.012) when compared with placebo. There were no significant changes in circulating peptide YY, glucagon-like peptide 1, oxyntomodulin, pancreatic polypeptide, leptin, and adiponectin concentrations. In summary, our results demonstrate that BNP exerts anorectic effects and reduces ghrelin concentrations in men. These data, taken together with the known cardiovascular properties of ghrelin, support the existence of a heart–gut–brain axis, which could be therapeutically targeted in patients with heart failure and obesity. American Diabetes Association 2012-10 2012-09-13 /pmc/articles/PMC3447894/ /pubmed/22698919 http://dx.doi.org/10.2337/db11-1466 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Pathophysiology
Vila, Greisa
Grimm, Gabriele
Resl, Michael
Heinisch, Birgit
Einwallner, Elisa
Esterbauer, Harald
Dieplinger, Benjamin
Mueller, Thomas
Luger, Anton
Clodi, Martin
B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title_full B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title_fullStr B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title_full_unstemmed B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title_short B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
title_sort b-type natriuretic peptide modulates ghrelin, hunger, and satiety in healthy men
topic Pathophysiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447894/
https://www.ncbi.nlm.nih.gov/pubmed/22698919
http://dx.doi.org/10.2337/db11-1466
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