GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K(+) Channel

Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses ins...

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Detalles Bibliográficos
Autores principales: Calabria, Andrew C., Li, Changhong, Gallagher, Paul R., Stanley, Charles A., De León, Diva D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447900/
https://www.ncbi.nlm.nih.gov/pubmed/22855730
http://dx.doi.org/10.2337/db12-0166

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