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De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the Absence of Xrcc4-Dependent Nonhomologous End Joining

Spontaneous copy number variant (CNV) mutations are an important factor in genomic structural variation, genomic disorders, and cancer. A major class of CNVs, termed nonrecurrent CNVs, is thought to arise by nonhomologous DNA repair mechanisms due to the presence of short microhomologies, blunt ends...

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Detalles Bibliográficos
Autores principales:	Arlt, Martin F., Rajendran, Sountharia, Birkeland, Shanda R., Wilson, Thomas E., Glover, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447954/ https://www.ncbi.nlm.nih.gov/pubmed/23028374 http://dx.doi.org/10.1371/journal.pgen.1002981

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