Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Genome-wide association studies have identified SNPs reproducibly associated with type 2 diabetes (T2D). We examined the effect of genetic predisposition to T2D on insulin sensitivity and secretion using detailed phenotyping in overweight individuals with no diagnosis of T2D. Furthermore, we investi...

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Detalles Bibliográficos
Autores principales: Walker, Celia G., Loos, Ruth J. F., Mander, Adrian P., Jebb, Susan A., Frost, Gary S., Griffin, Bruce A., Lovegrove, Julie A., Sanders, Thomas A. B., Bluck, Les J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448035/
https://www.ncbi.nlm.nih.gov/pubmed/22350825
http://dx.doi.org/10.1007/s12263-012-0284-8

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