A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed...

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Autores principales: Alter, Harvey J., Mikovits, Judy A., Switzer, William M., Ruscetti, Francis W., Lo, Shyh-Ching, Klimas, Nancy, Komaroff, Anthony L., Montoya, Jose G., Bateman, Lucinda, Levine, Susan, Peterson, Daniel, Levin, Bruce, Hanson, Maureen R., Genfi, Afia, Bhat, Meera, Zheng, HaoQiang, Wang, Richard, Li, Bingjie, Hung, Guo-Chiuan, Lee, Li Ling, Sameroff, Stephen, Heneine, Walid, Coffin, John, Hornig, Mady, Lipkin, W. Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448165/
https://www.ncbi.nlm.nih.gov/pubmed/22991430
http://dx.doi.org/10.1128/mBio.00266-12
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author Alter, Harvey J.
Mikovits, Judy A.
Switzer, William M.
Ruscetti, Francis W.
Lo, Shyh-Ching
Klimas, Nancy
Komaroff, Anthony L.
Montoya, Jose G.
Bateman, Lucinda
Levine, Susan
Peterson, Daniel
Levin, Bruce
Hanson, Maureen R.
Genfi, Afia
Bhat, Meera
Zheng, HaoQiang
Wang, Richard
Li, Bingjie
Hung, Guo-Chiuan
Lee, Li Ling
Sameroff, Stephen
Heneine, Walid
Coffin, John
Hornig, Mady
Lipkin, W. Ian
author_facet Alter, Harvey J.
Mikovits, Judy A.
Switzer, William M.
Ruscetti, Francis W.
Lo, Shyh-Ching
Klimas, Nancy
Komaroff, Anthony L.
Montoya, Jose G.
Bateman, Lucinda
Levine, Susan
Peterson, Daniel
Levin, Bruce
Hanson, Maureen R.
Genfi, Afia
Bhat, Meera
Zheng, HaoQiang
Wang, Richard
Li, Bingjie
Hung, Guo-Chiuan
Lee, Li Ling
Sameroff, Stephen
Heneine, Walid
Coffin, John
Hornig, Mady
Lipkin, W. Ian
author_sort Alter, Harvey J.
collection PubMed
description The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.
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spelling pubmed-34481652012-09-25 A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus Alter, Harvey J. Mikovits, Judy A. Switzer, William M. Ruscetti, Francis W. Lo, Shyh-Ching Klimas, Nancy Komaroff, Anthony L. Montoya, Jose G. Bateman, Lucinda Levine, Susan Peterson, Daniel Levin, Bruce Hanson, Maureen R. Genfi, Afia Bhat, Meera Zheng, HaoQiang Wang, Richard Li, Bingjie Hung, Guo-Chiuan Lee, Li Ling Sameroff, Stephen Heneine, Walid Coffin, John Hornig, Mady Lipkin, W. Ian mBio Research Article The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection. American Society of Microbiology 2012-09-18 /pmc/articles/PMC3448165/ /pubmed/22991430 http://dx.doi.org/10.1128/mBio.00266-12 Text en Copyright © 2012 Alter et al. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alter, Harvey J.
Mikovits, Judy A.
Switzer, William M.
Ruscetti, Francis W.
Lo, Shyh-Ching
Klimas, Nancy
Komaroff, Anthony L.
Montoya, Jose G.
Bateman, Lucinda
Levine, Susan
Peterson, Daniel
Levin, Bruce
Hanson, Maureen R.
Genfi, Afia
Bhat, Meera
Zheng, HaoQiang
Wang, Richard
Li, Bingjie
Hung, Guo-Chiuan
Lee, Li Ling
Sameroff, Stephen
Heneine, Walid
Coffin, John
Hornig, Mady
Lipkin, W. Ian
A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title_full A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title_fullStr A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title_full_unstemmed A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title_short A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus
title_sort multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448165/
https://www.ncbi.nlm.nih.gov/pubmed/22991430
http://dx.doi.org/10.1128/mBio.00266-12
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