Genetic Inhibition of CaMKII in Dorsal Striatal Medium Spiny Neurons Reduces Functional Excitatory Synapses and Enhances Intrinsic Excitability

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as occurs in Parkinson's disease as well as addiction. Although CaMKII has been extensively studied in the hippocampus wh...

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Detalles Bibliográficos
Autores principales: Klug, Jason R., Mathur, Brian N., Kash, Thomas L., Wang, Hui-Dong, Matthews, Robert T., Robison, A. J., Anderson, Mark E., Deutch, Ariel Y., Lovinger, David M., Colbran, Roger J., Winder, Danny G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448631/
https://www.ncbi.nlm.nih.gov/pubmed/23028932
http://dx.doi.org/10.1371/journal.pone.0045323

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