MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene

MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role of miR-330 in biological behaviors of human glioblastoma U87 and U251 cell lines and its molecular mechanism. SH3GL2 gene was identified as the target of miR-330. MiR-330 overexpr...

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Detalles Bibliográficos
Autores principales: Qu, Shengtao, Yao, Yilong, Shang, Chao, Xue, Yixue, Ma, Jun, Li, Zhen, Liu, Yunhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448729/
https://www.ncbi.nlm.nih.gov/pubmed/23029364
http://dx.doi.org/10.1371/journal.pone.0046010
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author Qu, Shengtao
Yao, Yilong
Shang, Chao
Xue, Yixue
Ma, Jun
Li, Zhen
Liu, Yunhui
author_facet Qu, Shengtao
Yao, Yilong
Shang, Chao
Xue, Yixue
Ma, Jun
Li, Zhen
Liu, Yunhui
author_sort Qu, Shengtao
collection PubMed
description MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role of miR-330 in biological behaviors of human glioblastoma U87 and U251 cell lines and its molecular mechanism. SH3GL2 gene was identified as the target of miR-330. MiR-330 overexpression was established by transfecting miR-330 precursor into U87 and U251 cells, and its effects on proliferation, migration, invasion, cell cycle and apoptosis were studied. Overexpression of miR-330 can enhance cellular proliferation, promote migration and invasion, activate cell cycle and also inhibit apoptosis in U87 and U251 cells. Collectively, these above-mentioned results suggest that miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma.
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spelling pubmed-34487292012-10-01 MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene Qu, Shengtao Yao, Yilong Shang, Chao Xue, Yixue Ma, Jun Li, Zhen Liu, Yunhui PLoS One Research Article MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role of miR-330 in biological behaviors of human glioblastoma U87 and U251 cell lines and its molecular mechanism. SH3GL2 gene was identified as the target of miR-330. MiR-330 overexpression was established by transfecting miR-330 precursor into U87 and U251 cells, and its effects on proliferation, migration, invasion, cell cycle and apoptosis were studied. Overexpression of miR-330 can enhance cellular proliferation, promote migration and invasion, activate cell cycle and also inhibit apoptosis in U87 and U251 cells. Collectively, these above-mentioned results suggest that miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. Public Library of Science 2012-09-21 /pmc/articles/PMC3448729/ /pubmed/23029364 http://dx.doi.org/10.1371/journal.pone.0046010 Text en © 2012 Qu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Qu, Shengtao
Yao, Yilong
Shang, Chao
Xue, Yixue
Ma, Jun
Li, Zhen
Liu, Yunhui
MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title_full MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title_fullStr MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title_full_unstemmed MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title_short MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene
title_sort microrna-330 is an oncogenic factor in glioblastoma cells by regulating sh3gl2 gene
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448729/
https://www.ncbi.nlm.nih.gov/pubmed/23029364
http://dx.doi.org/10.1371/journal.pone.0046010
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