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Aquaporin-1 Translocation and Degradation Mediates the Water Transportation Mechanism of Acetazolamide
BACKGROUND: Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448731/ https://www.ncbi.nlm.nih.gov/pubmed/23029347 http://dx.doi.org/10.1371/journal.pone.0045976 |