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Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and th...

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Detalles Bibliográficos
Autores principales:	Haerteis, Silke, Krappitz, Matteus, Bertog, Marko, Krappitz, Annabel, Baraznenok, Vera, Henderson, Ian, Lindström, Erik, Murphy, Jane E., Bunnett, Nigel W., Korbmacher, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448907/ https://www.ncbi.nlm.nih.gov/pubmed/22864553 http://dx.doi.org/10.1007/s00424-012-1138-3

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