Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats

We have built a rat's model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed...

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Detalles Bibliográficos
Autores principales: Miao, Zhimin, Lu, Shulai, Du, Na, Guo, Weiting, Zhang, Jidong, Song, Yu, Wang, Xuefeng, Ren, Wei, Wang, Yunlong, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449152/
https://www.ncbi.nlm.nih.gov/pubmed/23024464
http://dx.doi.org/10.1155/2012/459617
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author Miao, Zhimin
Lu, Shulai
Du, Na
Guo, Weiting
Zhang, Jidong
Song, Yu
Wang, Xuefeng
Ren, Wei
Wang, Yunlong
Jiang, Tao
author_facet Miao, Zhimin
Lu, Shulai
Du, Na
Guo, Weiting
Zhang, Jidong
Song, Yu
Wang, Xuefeng
Ren, Wei
Wang, Yunlong
Jiang, Tao
author_sort Miao, Zhimin
collection PubMed
description We have built a rat's model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.
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spelling pubmed-34491522012-09-28 Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats Miao, Zhimin Lu, Shulai Du, Na Guo, Weiting Zhang, Jidong Song, Yu Wang, Xuefeng Ren, Wei Wang, Yunlong Jiang, Tao Mediators Inflamm Research Article We have built a rat's model to investigate whether the hypothermia induced by adenosine 5′-monophosphate (5′-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats. Hindawi Publishing Corporation 2012 2012-09-13 /pmc/articles/PMC3449152/ /pubmed/23024464 http://dx.doi.org/10.1155/2012/459617 Text en Copyright © 2012 Zhimin Miao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Miao, Zhimin
Lu, Shulai
Du, Na
Guo, Weiting
Zhang, Jidong
Song, Yu
Wang, Xuefeng
Ren, Wei
Wang, Yunlong
Jiang, Tao
Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title_full Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title_fullStr Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title_full_unstemmed Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title_short Hypothermia Induced by Adenosine 5′-Monophosphate Attenuates Acute Lung Injury Induced by LPS in Rats
title_sort hypothermia induced by adenosine 5′-monophosphate attenuates acute lung injury induced by lps in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449152/
https://www.ncbi.nlm.nih.gov/pubmed/23024464
http://dx.doi.org/10.1155/2012/459617
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