Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations

Elevated plasma levels of lipoprotein-associated phospholipase A(2) (Lp-PLA2) activity have been shown to be associated with increased risk of coronary heart disease and an inhibitor of this enzyme is under development for the treatment of that condition. A Val279Phe null allele in this gene, that m...

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Detalles Bibliográficos
Autores principales: Song, K, Nelson, M R, Aponte, J, Manas, E S, Bacanu, S-A, Yuan, X, Kong, X, Cardon, L, Mooser, V E, Whittaker, J C, Waterworth, D M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449231/
https://www.ncbi.nlm.nih.gov/pubmed/21606947
http://dx.doi.org/10.1038/tpj.2011.20

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