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Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice with growing prevalence in developed countries. Several medical and interventional therapies, such as atrial specific drugs and pulmonary vein isolation, have demonstrated prevention of recurrences. How...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449334/ https://www.ncbi.nlm.nih.gov/pubmed/23015791 http://dx.doi.org/10.3389/fphys.2012.00370 |
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author | Salvador-Montañés, Oscar Gómez-Gallanti, Alfonso Garofalo, Daniel Noujaim, Sami F. Peinado, Rafael Filgueiras-Rama, David |
author_facet | Salvador-Montañés, Oscar Gómez-Gallanti, Alfonso Garofalo, Daniel Noujaim, Sami F. Peinado, Rafael Filgueiras-Rama, David |
author_sort | Salvador-Montañés, Oscar |
collection | PubMed |
description | Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice with growing prevalence in developed countries. Several medical and interventional therapies, such as atrial specific drugs and pulmonary vein isolation, have demonstrated prevention of recurrences. However, their suboptimal long-term success and significant rate of secondary effects have led to intensive research in the last decade focused on novel alternative and supplemental therapies. One such candidate is polyunsaturated fatty acids (PUFAs). Because of their biological properties, safety, simplicity, and relatively cheap cost, there is a special clinical interest in omega-3 PUFAs as a possible antiarrhythmic agent. Obtained from diets rich in fish, they represent one of the current supplemental therapies. At the cellular level, an increasing body of evidence has shown that n-3 PUFAs exert a variety of effects on cardiac ion channels, membrane dynamic properties, inflammatory cascade, and other targets related to AF prevention. In this article, we review the current basic and clinical evidence pertinent to n-3 PUFAs in AF treatment and prevention. We also discuss controversial outcomes among clinical studies and propose specific subsets of AF patients who will benefit most from n-3 PUFAs. |
format | Online Article Text |
id | pubmed-3449334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34493342012-09-26 Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates Salvador-Montañés, Oscar Gómez-Gallanti, Alfonso Garofalo, Daniel Noujaim, Sami F. Peinado, Rafael Filgueiras-Rama, David Front Physiol Physiology Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice with growing prevalence in developed countries. Several medical and interventional therapies, such as atrial specific drugs and pulmonary vein isolation, have demonstrated prevention of recurrences. However, their suboptimal long-term success and significant rate of secondary effects have led to intensive research in the last decade focused on novel alternative and supplemental therapies. One such candidate is polyunsaturated fatty acids (PUFAs). Because of their biological properties, safety, simplicity, and relatively cheap cost, there is a special clinical interest in omega-3 PUFAs as a possible antiarrhythmic agent. Obtained from diets rich in fish, they represent one of the current supplemental therapies. At the cellular level, an increasing body of evidence has shown that n-3 PUFAs exert a variety of effects on cardiac ion channels, membrane dynamic properties, inflammatory cascade, and other targets related to AF prevention. In this article, we review the current basic and clinical evidence pertinent to n-3 PUFAs in AF treatment and prevention. We also discuss controversial outcomes among clinical studies and propose specific subsets of AF patients who will benefit most from n-3 PUFAs. Frontiers Research Foundation 2012-09-17 /pmc/articles/PMC3449334/ /pubmed/23015791 http://dx.doi.org/10.3389/fphys.2012.00370 Text en Copyright © 2012 Salvador-Montañés, Gómez-Gallanti, Garofalo, Noujaim, Peinado and Filgueiras-Rama. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Physiology Salvador-Montañés, Oscar Gómez-Gallanti, Alfonso Garofalo, Daniel Noujaim, Sami F. Peinado, Rafael Filgueiras-Rama, David Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title | Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title_full | Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title_fullStr | Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title_full_unstemmed | Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title_short | Polyunsaturated Fatty Acids in Atrial Fibrillation: Looking for the Proper Candidates |
title_sort | polyunsaturated fatty acids in atrial fibrillation: looking for the proper candidates |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449334/ https://www.ncbi.nlm.nih.gov/pubmed/23015791 http://dx.doi.org/10.3389/fphys.2012.00370 |
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