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Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties

Therapeutic antibodies are well established drugs in diverse medical indications. Their success invigorates research on multi-specific antibodies in order to enhance drug efficacy by co-targeting of receptors and addressing key questions of emerging resistance mechanisms. Despite challenges in produ...

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Detalles Bibliográficos
Autores principales: Castoldi, R., Jucknischke, U., Pradel, L.P., Arnold, E., Klein, C., Scheiblich, S., Niederfellner, G., Sustmann, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449402/
https://www.ncbi.nlm.nih.gov/pubmed/22936109
http://dx.doi.org/10.1093/protein/gzs048