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Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers
Triptans are effective and well tolerated in acute migraine management but their exact mechanism of action is still debated. Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP). To examine this question, we examined whether suma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451653/ https://www.ncbi.nlm.nih.gov/pubmed/19266171 http://dx.doi.org/10.1007/s10194-009-0102-x |
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author | Hansen, Jakob Møller Petersen, Jesper Wienecke, Troels Olsen, Karsten Skovgaard Jensen, Lars Thorbjørn Ashina, Messoud |
author_facet | Hansen, Jakob Møller Petersen, Jesper Wienecke, Troels Olsen, Karsten Skovgaard Jensen, Lars Thorbjørn Ashina, Messoud |
author_sort | Hansen, Jakob Møller |
collection | PubMed |
description | Triptans are effective and well tolerated in acute migraine management but their exact mechanism of action is still debated. Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP). To examine this question, we examined whether sumatriptan modulate the baseline CGRP levels in vivo, under conditions without trigeminovascular system activation. We sampled blood from the internal and external jugular, the cubital veins, and the radial artery before and after administration of subcutaneous sumatriptan in 16 healthy volunteers. Repeated-measure ANOVA showed no interaction between catheter and time of sampling and thus no significant difference in CGRP between the four catheters (P = 0.75). CGRP did not change over time in the four compartments (P > 0.05). The relative changes in CGRP between baseline and maximal sumatriptan concentration did not differ between the four vascular compartments (P = 0.49). It was found that Sumatriptan did not change the levels of circulating CGRP in the intra or extracerebral circulation in healthy volunteers. This speaks against a direct CGRP-reducing effect of sumatriptan in vivo in humans when the trigemino vascular system is not activated. |
format | Online Article Text |
id | pubmed-3451653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-34516532012-11-29 Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers Hansen, Jakob Møller Petersen, Jesper Wienecke, Troels Olsen, Karsten Skovgaard Jensen, Lars Thorbjørn Ashina, Messoud J Headache Pain Original Triptans are effective and well tolerated in acute migraine management but their exact mechanism of action is still debated. Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP). To examine this question, we examined whether sumatriptan modulate the baseline CGRP levels in vivo, under conditions without trigeminovascular system activation. We sampled blood from the internal and external jugular, the cubital veins, and the radial artery before and after administration of subcutaneous sumatriptan in 16 healthy volunteers. Repeated-measure ANOVA showed no interaction between catheter and time of sampling and thus no significant difference in CGRP between the four catheters (P = 0.75). CGRP did not change over time in the four compartments (P > 0.05). The relative changes in CGRP between baseline and maximal sumatriptan concentration did not differ between the four vascular compartments (P = 0.49). It was found that Sumatriptan did not change the levels of circulating CGRP in the intra or extracerebral circulation in healthy volunteers. This speaks against a direct CGRP-reducing effect of sumatriptan in vivo in humans when the trigemino vascular system is not activated. Springer Milan 2009-03-06 2009-04 /pmc/articles/PMC3451653/ /pubmed/19266171 http://dx.doi.org/10.1007/s10194-009-0102-x Text en © Springer-Verlag 2009 |
spellingShingle | Original Hansen, Jakob Møller Petersen, Jesper Wienecke, Troels Olsen, Karsten Skovgaard Jensen, Lars Thorbjørn Ashina, Messoud Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title | Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title_full | Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title_fullStr | Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title_full_unstemmed | Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title_short | Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
title_sort | sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451653/ https://www.ncbi.nlm.nih.gov/pubmed/19266171 http://dx.doi.org/10.1007/s10194-009-0102-x |
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