The association between headache and Val158Met polymorphism in the catechol–O–methyltransferase gene: the HUNT Study

The catechol–O–methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. In the 1995–97 Nord–Trøndelag Health (HUNT) Study, the...

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Detalles Bibliográficos
Autores principales: Hagen, K., Pettersen, E., Stovner, L. J., Skorpen, F., Zwart, J.-A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2006
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451703/
https://www.ncbi.nlm.nih.gov/pubmed/16688411
http://dx.doi.org/10.1007/s10194-006-0281-7
Descripción
Sumario:The catechol–O–methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. In the 1995–97 Nord–Trøndelag Health (HUNT) Study, the association between the Val158Met polymorphism and headache was evaluated in a random sample of 2451 individuals. No association between Val158Met polymorphism and migraine was found. Among women, a lower prevalence of non–migrainous headache was found among individuals with the Val/Val genotype than among those with other genotypes (26.2% vs. 33.6%, p=0.04). That non–migrainous headache was less likely among women with the Val/Val genotype may be an incidental finding, but should be investigated in further studies.

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