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GABA and glutamate in migraine

GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothesized that anomalies of GABA and glutamate turn–over may play a role in migraine pathogenes...

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Autores principales: D’Andrea, Giovanni, Granella, Franco, Cataldini, Morena, Verdelli, Flavio, Balbi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451832/
http://dx.doi.org/10.1007/s101940170011
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author D’Andrea, Giovanni
Granella, Franco
Cataldini, Morena
Verdelli, Flavio
Balbi, Tiziana
author_facet D’Andrea, Giovanni
Granella, Franco
Cataldini, Morena
Verdelli, Flavio
Balbi, Tiziana
author_sort D’Andrea, Giovanni
collection PubMed
description GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothesized that anomalies of GABA and glutamate turn–over may play a role in migraine pathogenesis. In this review are discussed the evidences in favour of this hypothesis. A derangement of GABA may be an important factor in the occurrence of migraine attacks and their recurrence, whereas high level of glutamic acid may represent a biochemical marker of the neuronal hyperexcitability that may be the underlying cause of the aura. The pharmacological modulation of metabolism of both neurotransmitters is a promising approach to improve migraine therapy. In particular the studies presented here suggest that gabaergic drugs may be useful in migraine without aura, antiglutamatergic drugs are indicated to treat migraine with aura.
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spelling pubmed-34518322013-04-01 GABA and glutamate in migraine D’Andrea, Giovanni Granella, Franco Cataldini, Morena Verdelli, Flavio Balbi, Tiziana J Headache Pain Migraine and Pathophysiology GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothesized that anomalies of GABA and glutamate turn–over may play a role in migraine pathogenesis. In this review are discussed the evidences in favour of this hypothesis. A derangement of GABA may be an important factor in the occurrence of migraine attacks and their recurrence, whereas high level of glutamic acid may represent a biochemical marker of the neuronal hyperexcitability that may be the underlying cause of the aura. The pharmacological modulation of metabolism of both neurotransmitters is a promising approach to improve migraine therapy. In particular the studies presented here suggest that gabaergic drugs may be useful in migraine without aura, antiglutamatergic drugs are indicated to treat migraine with aura. Springer-Verlag 2001-09 /pmc/articles/PMC3451832/ http://dx.doi.org/10.1007/s101940170011 Text en © Springer-Verlag Italia 2001
spellingShingle Migraine and Pathophysiology
D’Andrea, Giovanni
Granella, Franco
Cataldini, Morena
Verdelli, Flavio
Balbi, Tiziana
GABA and glutamate in migraine
title GABA and glutamate in migraine
title_full GABA and glutamate in migraine
title_fullStr GABA and glutamate in migraine
title_full_unstemmed GABA and glutamate in migraine
title_short GABA and glutamate in migraine
title_sort gaba and glutamate in migraine
topic Migraine and Pathophysiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451832/
http://dx.doi.org/10.1007/s101940170011
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