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Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing
We recruited 49 patients with classical trigeminal neuralgia (TN) according to the latest guidelines of the International Classification of Headache Disorders, and divided them into an acute (≤30 days onset; 13 patients) and a chronic (>30 days onset; 36 patients) group. We used blink reflex stud...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451913/ https://www.ncbi.nlm.nih.gov/pubmed/20186560 http://dx.doi.org/10.1007/s10194-010-0198-z |
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author | Liao, Ming Feng Lee, Meng Hsieh, Mei Jen Cheng, Mei Yun Lee, Jiann Der Weng, Hsu Huei Ro, Long Sun |
author_facet | Liao, Ming Feng Lee, Meng Hsieh, Mei Jen Cheng, Mei Yun Lee, Jiann Der Weng, Hsu Huei Ro, Long Sun |
author_sort | Liao, Ming Feng |
collection | PubMed |
description | We recruited 49 patients with classical trigeminal neuralgia (TN) according to the latest guidelines of the International Classification of Headache Disorders, and divided them into an acute (≤30 days onset; 13 patients) and a chronic (>30 days onset; 36 patients) group. We used blink reflex study and current perception threshold (CPT) testing to evaluate the painful facial areas and contralateral non-painful areas of patients with classical TN. CPT 5 Hz examinations, which correlate with unmyelinated fiber function, showed significantly decreased CPTs in the acute stage (11.62 ± 6.99 vs. 18.69 ± 9.66, P = 0.025), but significantly increased CPTs in the chronic stage (26.67 ± 18.65 vs. 19.69 ± 13.70, P = 0.010) on the painful side when compared with the contralateral non-painful side. However, CPTs at 250 Hz (Aδ) and 2000 Hz (Aβ) examinations did not show significant differences between the painful and non-painful sides. In contrast, only three (3/49) patients showed an abnormal trigeminal nerve stimulation on the ipsilateral painful side by blink reflex study. The findings suggest that classical TN is not a simple large-myelinated nerve fiber dysfunction but a more complex process with a main dysfunction of unmyelinated nerve fibers. |
format | Online Article Text |
id | pubmed-3451913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-34519132012-11-29 Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing Liao, Ming Feng Lee, Meng Hsieh, Mei Jen Cheng, Mei Yun Lee, Jiann Der Weng, Hsu Huei Ro, Long Sun J Headache Pain Original We recruited 49 patients with classical trigeminal neuralgia (TN) according to the latest guidelines of the International Classification of Headache Disorders, and divided them into an acute (≤30 days onset; 13 patients) and a chronic (>30 days onset; 36 patients) group. We used blink reflex study and current perception threshold (CPT) testing to evaluate the painful facial areas and contralateral non-painful areas of patients with classical TN. CPT 5 Hz examinations, which correlate with unmyelinated fiber function, showed significantly decreased CPTs in the acute stage (11.62 ± 6.99 vs. 18.69 ± 9.66, P = 0.025), but significantly increased CPTs in the chronic stage (26.67 ± 18.65 vs. 19.69 ± 13.70, P = 0.010) on the painful side when compared with the contralateral non-painful side. However, CPTs at 250 Hz (Aδ) and 2000 Hz (Aβ) examinations did not show significant differences between the painful and non-painful sides. In contrast, only three (3/49) patients showed an abnormal trigeminal nerve stimulation on the ipsilateral painful side by blink reflex study. The findings suggest that classical TN is not a simple large-myelinated nerve fiber dysfunction but a more complex process with a main dysfunction of unmyelinated nerve fibers. Springer Milan 2010-02-26 2010-06 /pmc/articles/PMC3451913/ /pubmed/20186560 http://dx.doi.org/10.1007/s10194-010-0198-z Text en © Springer-Verlag 2010 |
spellingShingle | Original Liao, Ming Feng Lee, Meng Hsieh, Mei Jen Cheng, Mei Yun Lee, Jiann Der Weng, Hsu Huei Ro, Long Sun Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title | Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title_full | Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title_fullStr | Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title_full_unstemmed | Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title_short | Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
title_sort | evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451913/ https://www.ncbi.nlm.nih.gov/pubmed/20186560 http://dx.doi.org/10.1007/s10194-010-0198-z |
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