Association between migraine and HLA–DRB1 gene polymorphisms

We examined the distribution of HLA–DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased...

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Autores principales: Rainero, I., Fasano, E., Rubino, E., Rivoiro, C., Valfrè, W., Gallone, S., Savi, L., Gentile, S., Lo Giudice, R., De Martino, P., Dall’Omo, A. M., Pinessi, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2005
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452004/
https://www.ncbi.nlm.nih.gov/pubmed/16362659
http://dx.doi.org/10.1007/s10194-005-0180-3
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author Rainero, I.
Fasano, E.
Rubino, E.
Rivoiro, C.
Valfrè, W.
Gallone, S.
Savi, L.
Gentile, S.
Lo Giudice, R.
De Martino, P.
Dall’Omo, A. M.
Pinessi, L.
author_facet Rainero, I.
Fasano, E.
Rubino, E.
Rivoiro, C.
Valfrè, W.
Gallone, S.
Savi, L.
Gentile, S.
Lo Giudice, R.
De Martino, P.
Dall’Omo, A. M.
Pinessi, L.
author_sort Rainero, I.
collection PubMed
description We examined the distribution of HLA–DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA–DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA–DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.
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spelling pubmed-34520042012-11-29 Association between migraine and HLA–DRB1 gene polymorphisms Rainero, I. Fasano, E. Rubino, E. Rivoiro, C. Valfrè, W. Gallone, S. Savi, L. Gentile, S. Lo Giudice, R. De Martino, P. Dall’Omo, A. M. Pinessi, L. J Headache Pain Genetics We examined the distribution of HLA–DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA–DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA–DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region. Springer-Verlag 2005-07-20 2005-09 /pmc/articles/PMC3452004/ /pubmed/16362659 http://dx.doi.org/10.1007/s10194-005-0180-3 Text en © Springer-Verlag Italia 2005
spellingShingle Genetics
Rainero, I.
Fasano, E.
Rubino, E.
Rivoiro, C.
Valfrè, W.
Gallone, S.
Savi, L.
Gentile, S.
Lo Giudice, R.
De Martino, P.
Dall’Omo, A. M.
Pinessi, L.
Association between migraine and HLA–DRB1 gene polymorphisms
title Association between migraine and HLA–DRB1 gene polymorphisms
title_full Association between migraine and HLA–DRB1 gene polymorphisms
title_fullStr Association between migraine and HLA–DRB1 gene polymorphisms
title_full_unstemmed Association between migraine and HLA–DRB1 gene polymorphisms
title_short Association between migraine and HLA–DRB1 gene polymorphisms
title_sort association between migraine and hla–drb1 gene polymorphisms
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452004/
https://www.ncbi.nlm.nih.gov/pubmed/16362659
http://dx.doi.org/10.1007/s10194-005-0180-3
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