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Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients

Patients with chronic tension- type headache (CTTH) are the most difficult to treat. Tricyclic antidepressants are the first-line therapeutic agents, but their anticholinergic side effects limit their usage. Selective serotonin reuptake inhibitors (SSRI) with fewer side effects than tricyclic antide...

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Autores principales: Boz, Cavit, Altunayoglu, Vildan, Velioglu, Sibel, Ozmenoglu, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452139/
http://dx.doi.org/10.1007/s10194-003-0034-9
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author Boz, Cavit
Altunayoglu, Vildan
Velioglu, Sibel
Ozmenoglu, Mehmet
author_facet Boz, Cavit
Altunayoglu, Vildan
Velioglu, Sibel
Ozmenoglu, Mehmet
author_sort Boz, Cavit
collection PubMed
description Patients with chronic tension- type headache (CTTH) are the most difficult to treat. Tricyclic antidepressants are the first-line therapeutic agents, but their anticholinergic side effects limit their usage. Selective serotonin reuptake inhibitors (SSRI) with fewer side effects than tricyclic antidepressants have also been used in treatment of CTTH, but the results are conflicting. In this study, prophylactic action of sertraline in treatment of nondepressed patients with CTTH was investigated and compared with amitriptyline in a prospective, randomized, open label, parallel-group study. A 4-week baseline period was followed by a 12-week treatment period with either 50 mg sertraline (n=41 patients) or 25 mg amitriptyline (n=44 patients). Efficacies of treatments were determined by using a headache diary, in which patients recorded the occurrence, number, intensity and duration of headaches in days, analgesic drug consumption and any adverse events. Both drugs reduced headache symptoms and analgesic drug consumption at the first, second and third months of treatment compared to baseline values. There was significant superiority of amitriptyline in the headache symptoms and drug consumption reductions versus sertraline at the second and third months of treatment. Side effects were more favorable in the sertraline-treated patients, but dropouts were similar in both groups. These results suggest that both drugs were effective in the treatment of non-depressed patients with CTTH, but in comparison between groups, amitriptyline was more effective than sertraline.
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spelling pubmed-34521392012-11-29 Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients Boz, Cavit Altunayoglu, Vildan Velioglu, Sibel Ozmenoglu, Mehmet J Headache Pain Original Patients with chronic tension- type headache (CTTH) are the most difficult to treat. Tricyclic antidepressants are the first-line therapeutic agents, but their anticholinergic side effects limit their usage. Selective serotonin reuptake inhibitors (SSRI) with fewer side effects than tricyclic antidepressants have also been used in treatment of CTTH, but the results are conflicting. In this study, prophylactic action of sertraline in treatment of nondepressed patients with CTTH was investigated and compared with amitriptyline in a prospective, randomized, open label, parallel-group study. A 4-week baseline period was followed by a 12-week treatment period with either 50 mg sertraline (n=41 patients) or 25 mg amitriptyline (n=44 patients). Efficacies of treatments were determined by using a headache diary, in which patients recorded the occurrence, number, intensity and duration of headaches in days, analgesic drug consumption and any adverse events. Both drugs reduced headache symptoms and analgesic drug consumption at the first, second and third months of treatment compared to baseline values. There was significant superiority of amitriptyline in the headache symptoms and drug consumption reductions versus sertraline at the second and third months of treatment. Side effects were more favorable in the sertraline-treated patients, but dropouts were similar in both groups. These results suggest that both drugs were effective in the treatment of non-depressed patients with CTTH, but in comparison between groups, amitriptyline was more effective than sertraline. Springer-Verlag 2003-08 /pmc/articles/PMC3452139/ http://dx.doi.org/10.1007/s10194-003-0034-9 Text en © Springer-Verlag Italia 2003
spellingShingle Original
Boz, Cavit
Altunayoglu, Vildan
Velioglu, Sibel
Ozmenoglu, Mehmet
Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title_full Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title_fullStr Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title_full_unstemmed Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title_short Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
title_sort sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452139/
http://dx.doi.org/10.1007/s10194-003-0034-9
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