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Post-infectious new daily persistent headache may respond to intravenous methylprednisolone

New daily persistent headache (NDPH) is a subtype of chronic daily headache (CDH) that starts acutely and continues as a daily headache from the onset. It is considered as one of the most treatment refractory of all headache syndromes. The pathophysiology is largely unknown. Viral infections, extrac...

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Autores principales: Prakash, Sanjay, Shah, Nilima D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452180/
https://www.ncbi.nlm.nih.gov/pubmed/19936615
http://dx.doi.org/10.1007/s10194-009-0171-x
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author Prakash, Sanjay
Shah, Nilima D.
author_facet Prakash, Sanjay
Shah, Nilima D.
author_sort Prakash, Sanjay
collection PubMed
description New daily persistent headache (NDPH) is a subtype of chronic daily headache (CDH) that starts acutely and continues as a daily headache from the onset. It is considered as one of the most treatment refractory of all headache syndromes. The pathophysiology is largely unknown. Viral infections, extracranial surgery, and stressful life events are considered as triggers for the onset of NDPH. A few patients may have the onset of their symptoms during an infection. Here we report nine patients with NDPH like headache. All of them had a history suggestive of extracranial infections a few weeks prior to the onset of headache. All patients received intravenous methyl prednisolone (IV MPS) for 5 days. Intravenous MPS was followed by Oral steroids for 2–3 weeks in six patients. The relief of headache started between the second and fifth days of infusion in all patients. The steady improvement in headache continued and seven patients experienced almost complete improvement within 2 weeks. Two other patients showed complete improvement between 6 and 8 weeks after initiation of IV MPS therapy. We conclude that NDPH-like headache may occur as a post infectious process following a recent infection. We also speculate on the possible mechanisms of headache in our patients.
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spelling pubmed-34521802012-11-29 Post-infectious new daily persistent headache may respond to intravenous methylprednisolone Prakash, Sanjay Shah, Nilima D. J Headache Pain Original New daily persistent headache (NDPH) is a subtype of chronic daily headache (CDH) that starts acutely and continues as a daily headache from the onset. It is considered as one of the most treatment refractory of all headache syndromes. The pathophysiology is largely unknown. Viral infections, extracranial surgery, and stressful life events are considered as triggers for the onset of NDPH. A few patients may have the onset of their symptoms during an infection. Here we report nine patients with NDPH like headache. All of them had a history suggestive of extracranial infections a few weeks prior to the onset of headache. All patients received intravenous methyl prednisolone (IV MPS) for 5 days. Intravenous MPS was followed by Oral steroids for 2–3 weeks in six patients. The relief of headache started between the second and fifth days of infusion in all patients. The steady improvement in headache continued and seven patients experienced almost complete improvement within 2 weeks. Two other patients showed complete improvement between 6 and 8 weeks after initiation of IV MPS therapy. We conclude that NDPH-like headache may occur as a post infectious process following a recent infection. We also speculate on the possible mechanisms of headache in our patients. Springer Milan 2009-11-21 2010-02 /pmc/articles/PMC3452180/ /pubmed/19936615 http://dx.doi.org/10.1007/s10194-009-0171-x Text en © Springer-Verlag 2009
spellingShingle Original
Prakash, Sanjay
Shah, Nilima D.
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title_full Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title_fullStr Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title_full_unstemmed Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title_short Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
title_sort post-infectious new daily persistent headache may respond to intravenous methylprednisolone
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452180/
https://www.ncbi.nlm.nih.gov/pubmed/19936615
http://dx.doi.org/10.1007/s10194-009-0171-x
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