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Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine

The aim was to investigate the immunoreactivities for NOS enzymes in frontal cortex and meningeal vessels after chemical stimulation of the subarachnoid space of adolescent rats and the effect of sumatriptan pre-treatment on the immunoreactivities of the NOS enzymes. Male adolescent Wistar rats were...

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Autores principales: Kurul, Semra Hiz, Demirpence, Savas, Kiray, Müge, Tugyan, Kazim, Yilmaz, Osman, Kose, Galip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452203/
https://www.ncbi.nlm.nih.gov/pubmed/18688693
http://dx.doi.org/10.1007/s10194-008-0056-4
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author Kurul, Semra Hiz
Demirpence, Savas
Kiray, Müge
Tugyan, Kazim
Yilmaz, Osman
Kose, Galip
author_facet Kurul, Semra Hiz
Demirpence, Savas
Kiray, Müge
Tugyan, Kazim
Yilmaz, Osman
Kose, Galip
author_sort Kurul, Semra Hiz
collection PubMed
description The aim was to investigate the immunoreactivities for NOS enzymes in frontal cortex and meningeal vessels after chemical stimulation of the subarachnoid space of adolescent rats and the effect of sumatriptan pre-treatment on the immunoreactivities of the NOS enzymes. Male adolescent Wistar rats were used. Rats in group 1 did not taken intracisternal injection. Rats in group 2 were taken intracisternal autologous blood injection, but no sumatriptan pre-treatment. Rats in group 3 were taken intracisternal autologous blood injection, but they were taken sumatriptan pre-treatment. Tissue samples were investigated for the presence of NOS immunoreactivity. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly increased in group 2 compared to group 1. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly reduced in group 3 compared to group 2. These results suggest that, chemical stimulation of the subarachnoid space increased the immunoreactivities of NOS enzymes in the brain of adolescent rats. The increased NOS immunoreactivities could be antagonized by pre-treatment with sumatriptan.
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spelling pubmed-34522032012-11-29 Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine Kurul, Semra Hiz Demirpence, Savas Kiray, Müge Tugyan, Kazim Yilmaz, Osman Kose, Galip J Headache Pain Original The aim was to investigate the immunoreactivities for NOS enzymes in frontal cortex and meningeal vessels after chemical stimulation of the subarachnoid space of adolescent rats and the effect of sumatriptan pre-treatment on the immunoreactivities of the NOS enzymes. Male adolescent Wistar rats were used. Rats in group 1 did not taken intracisternal injection. Rats in group 2 were taken intracisternal autologous blood injection, but no sumatriptan pre-treatment. Rats in group 3 were taken intracisternal autologous blood injection, but they were taken sumatriptan pre-treatment. Tissue samples were investigated for the presence of NOS immunoreactivity. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly increased in group 2 compared to group 1. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly reduced in group 3 compared to group 2. These results suggest that, chemical stimulation of the subarachnoid space increased the immunoreactivities of NOS enzymes in the brain of adolescent rats. The increased NOS immunoreactivities could be antagonized by pre-treatment with sumatriptan. Springer Milan 2008-08-08 2008-10 /pmc/articles/PMC3452203/ /pubmed/18688693 http://dx.doi.org/10.1007/s10194-008-0056-4 Text en © Springer-Verlag 2008
spellingShingle Original
Kurul, Semra Hiz
Demirpence, Savas
Kiray, Müge
Tugyan, Kazim
Yilmaz, Osman
Kose, Galip
Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title_full Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title_fullStr Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title_full_unstemmed Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title_short Investigation of the immunoreactivities of NOS enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
title_sort investigation of the immunoreactivities of nos enzymes and the effect of sumatriptan in adolescent rats using an experimental model of migraine
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452203/
https://www.ncbi.nlm.nih.gov/pubmed/18688693
http://dx.doi.org/10.1007/s10194-008-0056-4
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