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Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study

There is a growing body of evidence implicating inflammatory cytokines and brain-derived neurotropic factor (BDNF) in the generation of migraine pain. No previous study evaluated BNDF levels during migraine attacks and there are conflicting results regarding tumor necrosis factor-alpha (TNF-alpha) s...

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Autores principales: Tanure, Marco Túlio A., Gomez, Rodrigo S., Hurtado, Rubens Carlos L., Teixeira, Antônio L., Domingues, Renan Barros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452273/
https://www.ncbi.nlm.nih.gov/pubmed/20556464
http://dx.doi.org/10.1007/s10194-010-0233-0
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author Tanure, Marco Túlio A.
Gomez, Rodrigo S.
Hurtado, Rubens Carlos L.
Teixeira, Antônio L.
Domingues, Renan Barros
author_facet Tanure, Marco Túlio A.
Gomez, Rodrigo S.
Hurtado, Rubens Carlos L.
Teixeira, Antônio L.
Domingues, Renan Barros
author_sort Tanure, Marco Túlio A.
collection PubMed
description There is a growing body of evidence implicating inflammatory cytokines and brain-derived neurotropic factor (BDNF) in the generation of migraine pain. No previous study evaluated BNDF levels during migraine attacks and there are conflicting results regarding tumor necrosis factor-alpha (TNF-alpha) serum levels. This study compared serum levels of TNF-alpha, soluble TNF receptors 1 and 2 (sTNF-R1 and sTNF-R2), and BDNF during migraine attacks and in headache-free periods. Nine patients with episodic migraine were clinically evaluated during a migraine attack and in a headache-free period. Blood sample of each patient in both occasions was collected and all serum was submitted to TNF-alpha, sTNF-R1, sTNF-R2, and BDNF determination by ELISA. There was no significant difference in the serum levels of TNF-alpha, sTNF-R1 and sTNF-R2 in migraine attack period and headache-free period. BDNF serum levels were significantly higher during migraine attack than in pain-free period. This is the first report showing that BDNF serum levels increase during migraine attack. This reinforces the view that BDNF may be implicated in the physiopathology of migraine.
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spelling pubmed-34522732012-11-29 Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study Tanure, Marco Túlio A. Gomez, Rodrigo S. Hurtado, Rubens Carlos L. Teixeira, Antônio L. Domingues, Renan Barros J Headache Pain Rapid Communication There is a growing body of evidence implicating inflammatory cytokines and brain-derived neurotropic factor (BDNF) in the generation of migraine pain. No previous study evaluated BNDF levels during migraine attacks and there are conflicting results regarding tumor necrosis factor-alpha (TNF-alpha) serum levels. This study compared serum levels of TNF-alpha, soluble TNF receptors 1 and 2 (sTNF-R1 and sTNF-R2), and BDNF during migraine attacks and in headache-free periods. Nine patients with episodic migraine were clinically evaluated during a migraine attack and in a headache-free period. Blood sample of each patient in both occasions was collected and all serum was submitted to TNF-alpha, sTNF-R1, sTNF-R2, and BDNF determination by ELISA. There was no significant difference in the serum levels of TNF-alpha, sTNF-R1 and sTNF-R2 in migraine attack period and headache-free period. BDNF serum levels were significantly higher during migraine attack than in pain-free period. This is the first report showing that BDNF serum levels increase during migraine attack. This reinforces the view that BDNF may be implicated in the physiopathology of migraine. Springer Milan 2010-06-17 2010-10 /pmc/articles/PMC3452273/ /pubmed/20556464 http://dx.doi.org/10.1007/s10194-010-0233-0 Text en © Springer-Verlag 2010
spellingShingle Rapid Communication
Tanure, Marco Túlio A.
Gomez, Rodrigo S.
Hurtado, Rubens Carlos L.
Teixeira, Antônio L.
Domingues, Renan Barros
Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title_full Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title_fullStr Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title_full_unstemmed Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title_short Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
title_sort increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452273/
https://www.ncbi.nlm.nih.gov/pubmed/20556464
http://dx.doi.org/10.1007/s10194-010-0233-0
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