High prevalence of patent foramen ovale in migraine with aura

In this study we evaluated the presence of patent foramen ovale (PFO) in a cohort of 25 consecutive patients suffering from migraine with aura (MA) during an attack presenting to the emergency ward of an Italian hospital. Patients underwent brain magnetic resonance imaging (MRI) with contrast medium...

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Autores principales: Ferrarini, G., Malferrari, G., Zucco, R., Gaddi, O., Norina, M., Pini, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452317/
https://www.ncbi.nlm.nih.gov/pubmed/16362645
http://dx.doi.org/10.1007/s10194-005-0154-5
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author Ferrarini, G.
Malferrari, G.
Zucco, R.
Gaddi, O.
Norina, M.
Pini, L. A.
author_facet Ferrarini, G.
Malferrari, G.
Zucco, R.
Gaddi, O.
Norina, M.
Pini, L. A.
author_sort Ferrarini, G.
collection PubMed
description In this study we evaluated the presence of patent foramen ovale (PFO) in a cohort of 25 consecutive patients suffering from migraine with aura (MA) during an attack presenting to the emergency ward of an Italian hospital. Patients underwent brain magnetic resonance imaging (MRI) with contrast medium, routine coagulation tests, contrast transcranial echocolour–coded sonography (c–TCCS) and transoesophageal echocardiography (TEE). Of the enrolled patients, 88.7% showed a PFO according to the c–TCCS test, whereas only in 72% TEE confirmed the presence of PFO. This discordance could be due to the fact that c–TCCS is more sensitive even with shunts with minimal capacity also located in the pulmonary vasculature. After surgical treatment of the PFO, MA disappeared within two months. Also, the treatment with warfarin as well as with acetylsalicylic acid and flunarizine was able to dramatically reduce the frequency of migraine attacks. These data indicate a higher prevalence of PFO in MA vs. normal population (OR=2.92) and could suggest that the presence of arteriovenous (AV) shunts could represent a trigger for MA attacks as well as for stroke, but more studies are needed to confirm this preliminary hypothesis.
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spelling pubmed-34523172012-11-29 High prevalence of patent foramen ovale in migraine with aura Ferrarini, G. Malferrari, G. Zucco, R. Gaddi, O. Norina, M. Pini, L. A. J Headache Pain Original In this study we evaluated the presence of patent foramen ovale (PFO) in a cohort of 25 consecutive patients suffering from migraine with aura (MA) during an attack presenting to the emergency ward of an Italian hospital. Patients underwent brain magnetic resonance imaging (MRI) with contrast medium, routine coagulation tests, contrast transcranial echocolour–coded sonography (c–TCCS) and transoesophageal echocardiography (TEE). Of the enrolled patients, 88.7% showed a PFO according to the c–TCCS test, whereas only in 72% TEE confirmed the presence of PFO. This discordance could be due to the fact that c–TCCS is more sensitive even with shunts with minimal capacity also located in the pulmonary vasculature. After surgical treatment of the PFO, MA disappeared within two months. Also, the treatment with warfarin as well as with acetylsalicylic acid and flunarizine was able to dramatically reduce the frequency of migraine attacks. These data indicate a higher prevalence of PFO in MA vs. normal population (OR=2.92) and could suggest that the presence of arteriovenous (AV) shunts could represent a trigger for MA attacks as well as for stroke, but more studies are needed to confirm this preliminary hypothesis. Springer-Verlag 2005-04-08 2005-04 /pmc/articles/PMC3452317/ /pubmed/16362645 http://dx.doi.org/10.1007/s10194-005-0154-5 Text en © Springer-Verlag Italia 2005
spellingShingle Original
Ferrarini, G.
Malferrari, G.
Zucco, R.
Gaddi, O.
Norina, M.
Pini, L. A.
High prevalence of patent foramen ovale in migraine with aura
title High prevalence of patent foramen ovale in migraine with aura
title_full High prevalence of patent foramen ovale in migraine with aura
title_fullStr High prevalence of patent foramen ovale in migraine with aura
title_full_unstemmed High prevalence of patent foramen ovale in migraine with aura
title_short High prevalence of patent foramen ovale in migraine with aura
title_sort high prevalence of patent foramen ovale in migraine with aura
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452317/
https://www.ncbi.nlm.nih.gov/pubmed/16362645
http://dx.doi.org/10.1007/s10194-005-0154-5
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